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DEFB4A Protein, Human, Recombinant

Catalog No. TMPJ-00667
Synonyms: DEFB4, DEFB4A, hBD-2, Beta-Defensin 2, Skin-Antimicrobial Peptide 1, β-Defensin 4A, SAP1, β-Defensin 2, BD-2, DEFB4B, DEFB2, DEFB102, Beta 2, Defensin, Beta-Defensin 4A, β2

β-Defensin 4A is a membrane-active cationic peptide that functions in inflammation and innate immune responses. There are at least 30 β-Defensins, which are distinguished from α-Defensins by the connectivity pattern of their three intermolecular disulfide bonds. Members of the Defensin family are highly similar in protein sequence. This gene encodes Defensin, DEFB4;, which has broad-spectrum antimicrobial activity and may play an important role in innate epithelial defense. They are highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. β-Defensin 4A has low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. The 45 amino acid mature human BD3 shares 38% and 33% amino acid sequence identity with mouse and rat BD3, respectively.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
DEFB4A Protein, Human, Recombinant
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 97.00
50 μg 5 days $ 272.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,730.00
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Biological Description
Technical Params
Product Properties
Description β-Defensin 4A is a membrane-active cationic peptide that functions in inflammation and innate immune responses. There are at least 30 β-Defensins, which are distinguished from α-Defensins by the connectivity pattern of their three intermolecular disulfide bonds. Members of the Defensin family are highly similar in protein sequence. This gene encodes Defensin, DEFB4;, which has broad-spectrum antimicrobial activity and may play an important role in innate epithelial defense. They are highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. β-Defensin 4A has low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. The 45 amino acid mature human BD3 shares 38% and 33% amino acid sequence identity with mouse and rat BD3, respectively.
Species Human
Expression System E. coli
Tag None
Accession Number O15263
Synonyms DEFB4, DEFB4A, hBD-2, Beta-Defensin 2, Skin-Antimicrobial Peptide 1, β-Defensin 4A, SAP1, β-Defensin 2, BD-2, DEFB4B, DEFB2, DEFB102, Beta 2, Defensin, Beta-Defensin 4A, β2
Amino Acid Gly24-Pro64
Construction Recombinant Human Beta-Defensin 4A is produced by our E.coli expression system and the target gene encoding Gly24-Pro64 is expressed.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 9 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Lyophilized from a 0.2 μm filtered solution of PBS, pH 7.4.
Reconstitution Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. 
Stability & Storage

Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months.
Shipping

The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below.
Research Background β-Defensin 4A is a membrane-active cationic peptide that functions in inflammation and innate immune responses. There are at least 30 β-Defensins, which are distinguished from α-Defensins by the connectivity pattern of their three intermolecular disulfide bonds. Members of the Defensin family are highly similar in protein sequence. This gene encodes Defensin, DEFB4;, which has broad-spectrum antimicrobial activity and may play an important role in innate epithelial defense. They are highly expressed in skin and tonsils, and to a lesser extent in trachea, uterus, kidney, thymus, adenoid, pharynx and tongue. β-Defensin 4A has low expression in salivary gland, bone marrow, colon, stomach, polyp and larynx. No expression in small intestine. The 45 amino acid mature human BD3 shares 38% and 33% amino acid sequence identity with mouse and rat BD3, respectively.

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Keywords

DEFB4A Protein, Human, Recombinant DEFB 102 b-Defensin 2 DEFB4 DEFB 2 BD 2 b 2 DEFB4A hBD-2 Beta-Defensin 2 Skin-Antimicrobial Peptide 1 β-Defensin 4A SAP1 β 2 SAP 1 β-Defensin 2 BD-2 DEFB-4 DEFB4B DEFB2 DEFB102 DEFB-102 Beta 2 Defensin SAP-1 DEFB-2 Beta-Defensin 4A BD2 DEFB 4 β2 b-Defensin 4A recombinant recombinant-proteins proteins protein

 

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