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Dirlotapide

Name: Dirlotapide
Brand: TargetMol
SKU: T15006
Price: 750 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T15006Cas No. 481658-94-0

Alias Slentrol, CP742033

Dirlotapide (CP742033) is an intestinal selective microsomal triglyceride transfer protein (MTP) inhibitor. It reduces body weight in diabetic dogs.Dirlotapide reduces food intake in a dose-dependent manner, possibly by increasing the release of peptide YY into the circulation.

Dirlotapide

🥰Excellent

Purity: 99.62%

Catalog No. T15006Alias Slentrol, CP742033Cas No. 481658-94-0

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$750	In Stock	In Stock
5 mg	$1,530	In Stock	In Stock
10 mg	$1,980	In Stock	In Stock
25 mg	$2,970	In Stock	In Stock
50 mg	$4,150	In Stock	In Stock
100 mg	$5,580	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Purity:99.62%

ee:96.14%

Appearance:Solid

Color:White

Resource Download

COA CSFC FNMR LCMS ORP HNMR

Product Introduction

Bioactivity

Description	Dirlotapide (CP742033) is an intestinal selective microsomal triglyceride transfer protein (MTP) inhibitor. It reduces body weight in diabetic dogs.Dirlotapide reduces food intake in a dose-dependent manner, possibly by increasing the release of peptide YY into the circulation.
Targets&IC50	HepG2 cells:2.7 nM
In vivo	Dirlotapide (0.5 mg/kg; oral; dogs) results in a high rate of weight loss (3.3% weekly) anorexia, emesis, and loose stools for some dogs. Dirlotapide produces weight loss by both reducing appetite (about 90% of the weight loss activity) and by increasing fecal fat excretion (about 10% of the weight loss activity).[1] Dirlotapide (0.3 mg/kg; oral; once daily; dogs) has a small but significant (P=0.018) decrease (6.16 ± 2.22%, mean ± SD) in crude fat digestibility compared with the placebo-treated food-restricted dogs, but no difference in crude protein, dry matter, or energy digestibility is observed. Dirlotapide effectively reduces appetite and energy intake without affecting nutrient digestibility, except for a minimal decrease in fat digestibility.[2]
Synonyms	Slentrol, CP742033

Chemical Properties

Molecular Weight	674.71
Formula	C₄₀H₃₃F₃N₄O₃
Cas No.	481658-94-0
Smiles	CN(Cc1ccccc1)C(=O)[C@@H](NC(=O)c1cc2cc(NC(=O)c3ccccc3-c3ccc(cc3)C(F)(F)F)ccc2n1C)c1ccccc1
Relative Density.	1.25 g/cm3 (Predicted)

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 262.5 mg/mL (389.06 mM), Sonication is recommended.

H2O: < 1 mg/mL (insoluble or slightly soluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.4821 mL	7.4106 mL	14.8212 mL	74.1059 mL
5 mM	0.2964 mL	1.4821 mL	2.9642 mL	14.8212 mL
10 mM	0.1482 mL	0.7411 mL	1.4821 mL	7.4106 mL
20 mM	0.0741 mL	0.3705 mL	0.7411 mL	3.7053 mL
50 mM	0.0296 mL	0.1482 mL	0.2964 mL	1.4821 mL
100 mM	0.0148 mL	0.0741 mL	0.1482 mL	0.7411 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc