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JT010

Name: JT010
Brand: TargetMol
SKU: T15628
Price: 29 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T15628Cas No. 917562-33-5

JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).

JT010

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🥰Excellent

Purity: 99.75%

Catalog No. T15628Cas No. 917562-33-5

JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
2 mg	$29	In Stock	In Stock
5 mg	$48	In Stock	In Stock
10 mg	$77	In Stock	In Stock
25 mg	$158	In Stock	In Stock
50 mg	$253	In Stock	In Stock
100 mg	$377	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$53	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.75%

Appearance:Solid

Color:Orange

Resource Download

COA LCMS HNMR

Product Introduction

JT010 AI Summary

JT010 shows a slight and insignificant inhibition (-0.2%) of the SARS-CoV-2 3CL-Pro protease at a concentration of 20µM. Additionally, it exhibits antiviral activity by inhibiting SARS-CoV-2 induced cytotoxicity in VERO-6 cells at a concentration of 10µM after 48 hours exposure to 0.01 MOI SARS-CoV-2 virus, with an inhibition rate of -0.3%, as determined by high content imaging. Furthermore, JT010 demonstrates cytotoxic activity against human HepG2 cells, with an IC50 value of 1500.0 nM as assessed by the CellTiter-Glo luminescent cell viability assay..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	JT010 is an effective agonist of TRPA1 (EC50 = 0.65 nM).
Targets&IC50	TRPA1:0.65 nM (EC50)

Chemical Properties

Molecular Weight	354.85
Formula	C₁₆H₁₉ClN₂O₃S
Cas No.	917562-33-5
Smiles	COCCCN(C(=O)CCl)c1nc(cs1)-c1ccc(OC)cc1
Relative Density.	1.265 g/cm3 (Predicted)

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (140.9 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.8181 mL	14.0905 mL	28.1809 mL	140.9046 mL
5 mM	0.5636 mL	2.8181 mL	5.6362 mL	28.1809 mL
10 mM	0.2818 mL	1.4090 mL	2.8181 mL	14.0905 mL
20 mM	0.1409 mL	0.7045 mL	1.4090 mL	7.0452 mL
50 mM	0.0564 mL	0.2818 mL	0.5636 mL	2.8181 mL
100 mM	0.0282 mL	0.1409 mL	0.2818 mL	1.4090 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc