Shopping Cart

Your shopping cart is currently empty

Zatebradine hydrochloride

Name: Zatebradine hydrochloride
Brand: TargetMol
SKU: T13387L
Price: 457 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13387LCas No. 91940-87-3

Alias UL-FS-49CL, UL-FS-49

Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochloride blocks slow inward currents through human HCN1, HCN2, HCN3, and HCN4 channels with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM, and 1.88 µM, respectively.

Zatebradine hydrochloride

🥰Excellent

Purity: 97%

Catalog No. T13387LAlias UL-FS-49CL, UL-FS-49Cas No. 91940-87-3

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$45	-	In Stock
10 mg	$71	-	In Stock
25 mg	$157	-	In Stock
50 mg	$297	-	In Stock
100 mg	$457	-	In Stock
500 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$49	-	In Stock

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:97%

Resource Download

COA HPLC HNMR

Product Introduction

Bioactivity

Description	Zatebradine hydrochloride (UL-FS-49CL) is a highly effective and effective HCN Channel inhibitor (IC50:1.96 µM). HCN Channel is an effective hyperpolarization activated loop nucleotide gated channel. Zatebradine hydrochloride blocks slow inward currents through human HCN1, HCN2, HCN3, and HCN4 channels with IC50 values of 1.83 µM, 2.21 µM, 1.90 µM, and 1.88 µM, respectively.
Targets&IC50	HCN2:2.21 µM, HCN3:1.90 µM, HCN:1.96 μM, HCN1:1.83 µm, HCN4:1.88 µM
In vitro	Zatebradine demonstrates a use-dependent inhibitory effect on the cardiac pacemaker current in rabbit sino-atrial node cells, with an observed Kd value of 480 nM.[2]
In vivo	Zatebradine hydrochloride (0-20 mg/kg; i.p.; for 30 minutes; male C57/Bl6-mice) decreases the heart rate dose-dependently from 600 to 200 bpm (ED50: 1.8 mg/kg).[1]
Synonyms	UL-FS-49CL, UL-FS-49

Chemical Properties

Molecular Weight	493.04
Formula	C₂₆H₃₇ClN₂O₅
Cas No.	91940-87-3
Smiles	Cl.COc1ccc(CCN(C)CCCN2CCc3cc(OC)c(OC)cc3CC2=O)cc1OC
Relative Density.	1.115g/cm3
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 90.0 mg/mL (182.5 mM), Sonication is recommended.

H2O: 90.0 mg/mL (182.5 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 3.3 mg/mL (6.69 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO/H2O

	1mg	5mg	10mg	50mg
1 mM	2.0282 mL	10.1412 mL	20.2823 mL	101.4117 mL
5 mM	0.4056 mL	2.0282 mL	4.0565 mL	20.2823 mL
10 mM	0.2028 mL	1.0141 mL	2.0282 mL	10.1412 mL
20 mM	0.1014 mL	0.5071 mL	1.0141 mL	5.0706 mL
50 mM	0.0406 mL	0.2028 mL	0.4056 mL	2.0282 mL
100 mM	0.0203 mL	0.1014 mL	0.2028 mL	1.0141 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc