Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty
TargetMol | Tags Metabolism
ANGPTL
(4)
ATP Citrate Lyase
(15)
Acetyl-CoA Carboxylase
(32)
Aconitase
(2)
Acyltransferase
(145)
Adenosine Deaminase
(16)
AhR
(31)
Amino Acids and Derivatives
(1026)
Aminopeptidase
(70)
Amylase
(41)
Angiotensin-converting Enzyme (ACE)
(172)
Apolipoprotein
(9)
CETP
(17)
CPT
(5)
Calcium Channel
(628)
Carbonic Anhydrase
(215)
Casein Kinase
(159)
Cytochromes P450
(491)
DHFR
(58)
Decarboxylase
(7)
Dehydrogenase
(468)
Drug Metabolite
(587)
Endogenous Metabolite
(3224)
Epoxide Hydrolase
(57)
FAAH
(72)
FABP
(15)
FXR
(78)
Factor VIII
(6)
Factor VIIa
(5)
Factor Xa
(92)
Fatty Acid Synthase
(70)
GSNOR
(3)
Glucokinase
(71)
Glucosidase
(219)
Glutathione Peroxidase
(73)
Glyoxalase
(17)
HIF/HIF Prolyl-Hydroxylase
(194)
HMG-CoA Reductase
(69)
HSP
(264)
Hexokinase
(9)
Hydrogenase
(2)
Hydroxylase
(45)
IDO
(94)
Indoleamine 2,3-Dioxygenase (IDO)
(98)
Isocitrate Dehydrogenase (IDH)
(46)
LDL
(26)
LDLR
(14)
Lipase
(37)
Lipid
(44)
Liposome
(442)
Lipoxygenase
(194)
Liver X Receptor
(51)
MAGL
(61)
MAO
(108)
Mitochondrial Metabolism
(212)
N-Acetylglucosaminyltransferase
(1)
NADPH
(62)
NAMPT
(44)
NEDD4-1
(3)
NEDD8
(8)
NUDIX hydrolase
(2)
Neprilysin
(31)
PAI-1
(38)
PDE
(528)
PGK1
(3)
PKM
(43)
PPAR
(386)
Phosphatase
(432)
Phospholipase
(201)
Phosphorylase
(21)
Photosystem (PS)
(5)
Procollagen C Proteinase
(1)
Prolyl Endopeptidase (PREP)
(33)
RAR/RXR
(12)
REV-ERB
(9)
ROR
(96)
Reactive Oxygen Species
(773)
Reductase
(121)
Retinoid Receptor
(109)
SGK
(24)
Serine/threonin kinase
(90)
Stearoyl-CoA Desaturase (SCD)
(29)
Taste receptor
(6)
Thioredoxin
(2)
Transaminase
(3)
Transferase
(222)
Transketolase
(9)
UGT
(17)
Vitamin
(89)
Xanthine Oxidase
(73)
glycosidase
(28)
hCE
(2)
stilbene oxidase
(1)
transporter
(87)

Glutathione Peroxidase

Glutathione peroxidase (GPx) is the general name of an enzyme family with peroxidase activity whose main biological role is to protect the organism from oxidative damage. The biochemical function of glutathione peroxidase is to reduce lipid hydroperoxides to their corresponding alcohols and to reduce free hydrogen peroxide to water.

RSL3
T36461219810-16-8
RSL3 (RSL3 1S) is an inhibitor of GPX4, and inhibits system xc- that blocks GSH synthesis (IC50=100 nM). RSL3 is a VDAC-independent activator of ferroptosis that is selective for tumor cells carrying oncogenic RAS.
  • $33
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
ML162
T89701035072-16-2
ML162 is a covalent glutathione peroxidase 4 (GPX4) inhibitor that induces ferroptosis. ML162 has antitumor activity and selectively inhibits cell lines expressing mutant RAS oncogenes.
  • $38
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Mitiperstat
T610281933460-19-5
Mitiperstat is a potent myeloperoxidase (MPO) inhibitor that is effective in preventing cardiovascular diseases such as heart failure and coronary artery disease.
  • $158
In Stock
Size
QTY
JKE-1674
T373142421119-60-8
JKE-1674 is an orally active glutathione peroxidase 4 (GPX4) inhibitor and the active metabolite of ML-210, which is converted to butyronitrile oxide JKE-1777. JKE-1674 kills LOX-IMVI cells in the same manner as ML-210 and is completely rescued by ferroptosis inhibitors.
  • $44
In Stock
Size
QTY
TargetMol | Citations Cited
Solasonine
T390119121-58-5
Solasonine exerts leishmanicidal activity against promastigote forms of L. amazonensis.
  • $37
In Stock
Size
QTY
ML-210
T83751360705-96-9
ML-210 (CID 49766530) is a glutathione peroxidase 4 (GPX4) inhibitor (EC50=30 nM) that is covalent and selective. ML-210 has antitumor activity and induces ferroptosis.
  • $34
In Stock
Size
QTY
TargetMol | Citations Cited
N-Acetyl lysyltyrosylcysteine amide
T380631287585-40-3
N-Acetyl lysyltyrosylcysteine amide is a non-toxic, potent, reversible, and specific myeloperoxidase (MPO) tripeptide inhibitor that effectively inhibits MPO production in vivo, attenuates neuronal damage, preserves brain tissue and neurological function post-stroke, and inhibits MPO-dependent hypochlorite (HOCl) production, protein nitration, and LDL oxidation. It is also used in the study of bronchial dysplasia.
  • $72
In Stock
Size
QTY
NBDHEX
T12189787634-60-0
NBDHEX is a potent inhibitor of glutathione S-transferase P1-1 (GSTP1-1) .
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Gingerenone A
TN5770128700-97-0
Gingerenone A is an effective Nrf2-Gpx4 activator. It is a small molecule compound isolated from ginger. It has anti-cancer activity, can prolong the cell cycle of cancer cells, and can inhibit dextran sodium sulfate (DSS)-induced colitis. Ferroptosis in secondary liver injury (SLI) in mice.
  • $41
In Stock
Size
QTY
5-Aminosalicylic Acid
T064689-57-6
5-Aminosalicylic Acid (5-ASA) is a specific PPARγ agonist and also inhibits P21-activated kinase 1(PAK1) and NF-Κb. 5-Aminosalicylic Acid has anti-cancer and anti-inflammatory activities. 5-Aminosalicylic acid can inhibit the activity of osteopontin (OPN).
  • $45
In Stock
Size
QTY
TargetMol | Inhibitor Hot
TargetMol | Citations Cited
Melatonin
T165973-31-4
Melatonin (Melatonine) is a natural hormone secreted by the pineal gland that activates melatonin receptors. Melatonin is a hormone that regulates the biological clock and also has antioxidant and anti-inflammatory activities.
  • $31
In Stock
Size
QTY
TargetMol | Citations Cited
PKUMDL-LC-101-D04
T369352143896-83-5
PKUMDL-LC-101-D04 is a potent allosteric activator of glutathione peroxidase 4 (GPX4), a regulator of ferroptosis. GPX4 activity was increased to 150% of control levels when used at a concentration of 20 μM in a cell-free assay, and at a concentration of 61 μM in wild-type, but not Gpx4-/-, mouse embryonic fibroblast (MEF) extracts.PKUMDL-LC-101-D04 (200 μM) reduced cholesterol peroxide-induced MEF death.
  • $77
In Stock
Size
QTY
Eubulus-A80
T601672703776-20-7
Eubulus-A80 is a anti-tumor agent (WO2021/183702, Compound A80).
  • $195
In Stock
Size
QTY
azd8309
T25131333742-48-6In house
AZD8309 is a potent, orally available antagonist of the chemokine receptor CXCR2 that regulates neutrophil transport, significantly reduces MPO in the pancreas and lung, and decreases trypsin and elastase activity in the pancreas.AZD8309 can be used to study a range of inflammatory diseases.
  • $129
In Stock
Size
QTY
GSTO1-IN-1
T11505568544-03-6
GSTO1-IN-1 is a potent glutathione S-transferase omega 1 inhibitor (GSTO1) with an IC50 of 31 nM.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
Carmofur
T130761422-45-5
Carmofur (HCFU) is a highly potent acid ceramidase inhibitor, used in the treatment of breast and colorectal cancer. Carmofur has been known to induce leukoencephalopathy.
  • $34
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TargetMol | Citations Cited
PF-1355
T35111435467-38-1
PF-1355 (PF 06281355) is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.
  • $30
In Stock
Size
QTY
TargetMol | Inhibitor Sale
TLK117
T8424152684-53-2
TLK117 is an inhibitor of GSTs that reduces the severity of pulmonary fibrosis and can be used to study idiopathic pulmonary fibrosis.
  • $149
In Stock
Size
QTY
GPX4-IN-5
T777552922824-09-5
GPX4-IN-5 is a small molecule covalent GPX4 inhibitor (IC50: 0.12 μM) with antitumour activity.GPX4-IN-5 induces ferroptosis and can be used for the prevention and treatment of triple-negative breast cancer (TNBC).
  • $45
In Stock
Size
QTY
AZD5904
T14379618913-30-7
AZD5904 is a potent and irreversible human Myeloperoxidase (MPO) inhibitor(IC50 of 140 nM and has similar potency in mouse and rat).
  • $31
In Stock
Size
QTY
LAS17
T399062362527-67-9
LAS17 is a selective and highly effective inhibitor of glutathione S-transferase Pi (GSTP1), which inhibits GSTP1 activity in vitro in a concentration-dependent manner. LAS17 has anti-tumor activity and inhibits breast cancer cell growth.
  • $249
In Stock
Size
QTY
Verdiperstat
T5463890655-80-8
Verdiperstat (AZD 3241) is a selective, irreversible and orally active myeloperoxidase inhibitor, with an IC50 of 630 nM, and can be used in the research of neurodegenerative brain disorders.
  • $32
In Stock
Size
QTY
Nabumetone
T125842924-53-8
Nabumetone (BRL14777)(BRL14777) is a non-steroidal anti-inflammatory drug and its active metabolite 6MNA inhibits the enzymes cyclo-oxygenase I and II.
  • $49
In Stock
Size
QTY
Ezatiostat
T5097168682-53-9
Ezatiostat (TER199(free base)) is a tripeptide analog of glutathione that can selectively inhibit GSTP1-1 catalytic activity.
  • $35
In Stock
Size
QTY