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Febuxostat sodium

Catalog No. T61060 CAS 1140907-13-6

Febuxostat (TEI 6720) sodium has the potential in gout and hyperuricemia research which is a potent, selective and non-purine inhibitor of xanthine oxidase (XO) with a Ki value of 0.6 nM [1] [2] [3].

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Febuxostat sodium, CAS 1140907-13-6

Pack Size	Availability	Price/USD
25 mg	6-8 weeks	$ 1,520.00
50 mg	6-8 weeks	$ 1,980.00
100 mg	6-8 weeks	$ 2,500.00

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This compound is a customized synthesis product. We have a strong synthesis team with excellent synthesis technology and capabilities. However, due to various objective factors, there is a low probability that the synthesis will not be successful. If you need to learn more, please feel free to consult us, we will serve you wholeheartedly.

Biological Description

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Description	Febuxostat (TEI 6720) sodium has the potential in gout and hyperuricemia research which is a potent, selective and non-purine inhibitor of xanthine oxidase (XO) with a Ki value of 0.6 nM [1] [2] [3].
In vitro	Febuxostat sodium exhibits potent mixed-type inhibition against purified bovine milk xanthine oxidase, demonstrating inhibitory effects on both the oxidized and reduced forms of the enzyme, as evidenced by K i and K i ' values of 0.6 nM and 3.1 nM, respectively [1].
In vivo	Febuxostat sodium, at varying dosages and treatment durations, has been observed to significantly mitigate adverse conditions in several experimental models. Administered daily at 5-6 mg/kg for 4 weeks to rats on a high-fructose diet (60% fructose) for 8 weeks, it substantially lowers glomerular pressure, renal vasoconstriction, and the afferent arteriolar area as compared to rats on the same diet without febuxostat, yet it does not affect rats on a standard diet [2]. A lower dose (3-4 mg/kg, orally) combined with oxonic acid (750 mg/kg, orally) for 4 weeks effectively prevents renal injury in 5/6 nephrectomy rats, with or without hyperuricemia [3]. Additionally, at 2.5 mg/kg taken orally for 12 weeks, it inhibits plaque formation in ApoE / mice and reduces ROS levels in the aortic walls of these atherosclerotic mice [4]. A higher dose (15.6 mg/kg, orally, once daily for 21 consecutive days) displays an antidepressant effect by significantly reducing immobility time in the Forced Swim Test in mice [5]. Moreover, when combined with doxorubicin at 10 mg/kg, orally, for 21 days, it greatly decreases nephrotoxicity markers and inflammatory mediators, restores normal oxidative stress biomarker values, and reduces renal caspase-3 expression [6].

Molecular Weight	338.36
Formula	C16H15N2NaO3S
CAS No.	1140907-13-6

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Powder: -20°C for 3 years | In solvent: -80°C for 1 year

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

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Febuxostat sodium 1140907-13-6 inhibitor inhibit

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