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AKT-IN-6

🥰Excellent
Catalog No. T36310Cas No. 1430056-54-4
Alias INCB-047775

AKT-IN-6 (INCB-047775) has an inhibitory effect on ATK. Akt is an important component of cellular signaling for growth factors, cytokines, and other cell stimuli. Abnormal Akt activation has been associated with the development of type 2 diabetes mellitus and cancer.

AKT-IN-6

AKT-IN-6

🥰Excellent
Purity: 98.68%
Catalog No. T36310Alias INCB-047775Cas No. 1430056-54-4
AKT-IN-6 (INCB-047775) has an inhibitory effect on ATK. Akt is an important component of cellular signaling for growth factors, cytokines, and other cell stimuli. Abnormal Akt activation has been associated with the development of type 2 diabetes mellitus and cancer.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$30In StockIn Stock
5 mg$68In StockIn Stock
10 mg$113In StockIn Stock
25 mg$228In StockIn Stock
50 mg$372In StockIn Stock
100 mg$596In StockIn Stock
200 mg$847-In Stock
1 mL x 10 mM (in DMSO)$76In StockIn Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Batch Information

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Purity:98.68%
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COA LCMS HNMR

Product Introduction

Bioactivity
Description
AKT-IN-6 (INCB-047775) has an inhibitory effect on ATK. Akt is an important component of cellular signaling for growth factors, cytokines, and other cell stimuli. Abnormal Akt activation has been associated with the development of type 2 diabetes mellitus and cancer.
SynonymsINCB-047775
Chemical Properties
Molecular Weight389.43
FormulaC22H20FN5O
Cas No.1430056-54-4
SmilesCn1ncc(C#N)c1-c1ccc2C(=O)N(Cc2c1)[C@H](CN)Cc1cccc(F)c1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 112.5 mg/mL (288.9 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween 80+45% Saline: 4 mg/mL (10.27 mM), Sonication is recommended.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5679 mL12.8393 mL25.6786 mL128.3928 mL
5 mM0.5136 mL2.5679 mL5.1357 mL25.6786 mL
10 mM0.2568 mL1.2839 mL2.5679 mL12.8393 mL
20 mM0.1284 mL0.6420 mL1.2839 mL6.4196 mL
50 mM0.0514 mL0.2568 mL0.5136 mL2.5679 mL
100 mM0.0257 mL0.1284 mL0.2568 mL1.2839 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
mg/kg
g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

INCB047775INCB 047775AKT-IN-6Akt
Related Tags: buy AKT-IN-6 | purchase AKT-IN-6 | AKT-IN-6 cost | order AKT-IN-6 | AKT-IN-6 chemical structure | AKT-IN-6 formula | AKT-IN-6 molecular weight
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