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TMX-4100

Name: TMX-4100
Brand: TargetMol
SKU: T39913
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T39913Cas No. 2367619-63-2

Alias TMX4100

TMX-4100, a selective phosphodiesterase 6D (PDE6D) degrader, demonstrates high degradation preference (DC50 <200 nM) in MOLT4, Jurkat, and MM.1S cells. This compound can be used for multiple myeloma research.

TMX-4100

🥰Excellent

Purity: 99.10%

Catalog No. T39913Alias TMX4100Cas No. 2367619-63-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	-	In Stock
5 mg	$247	-	In Stock
10 mg	$396	-	In Stock
25 mg	$728	-	In Stock
50 mg	$987	-	In Stock
100 mg	$1,390	-	In Stock
200 mg	$1,870	-	In Stock
1 mL x 10 mM (in DMSO)	$272	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.10%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TMX-4100, a selective phosphodiesterase 6D (PDE6D) degrader, demonstrates high degradation preference (DC50 <200 nM) in MOLT4, Jurkat, and MM.1S cells. This compound can be used for multiple myeloma research.
In vitro	Methods: MOLT4, Jurkat, and MM.1S cells were treated with TMX-4100 (40nM, 200nM, 1μM), and the expression of target proteins was detected by Western blotting. Results: TMX-4100 maintained its high degradation preference for PDE6D in MOLT4, Jurkat, and MM.1S cells, with DC50 values less than 200 nM after 4 hours of treatment at doses up to 1 μM. [1]
Synonyms	TMX4100

Chemical Properties

Molecular Weight	262.29
Formula	C₁₁H₁₀N₄O₂S
Cas No.	2367619-63-2
Smiles	O=C1NC(=O)C(N2N=NC(=C2)C3=CSC=C3)CC1
Relative Density.	1.65 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (305.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (3.81 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8126 mL	19.0629 mL	38.1257 mL	190.6287 mL
5 mM	0.7625 mL	3.8126 mL	7.6251 mL	38.1257 mL
10 mM	0.3813 mL	1.9063 mL	3.8126 mL	19.0629 mL
20 mM	0.1906 mL	0.9531 mL	1.9063 mL	9.5314 mL
50 mM	0.0763 mL	0.3813 mL	0.7625 mL	3.8126 mL
100 mM	0.0381 mL	0.1906 mL	0.3813 mL	1.9063 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc