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TMX-4100

Name: TMX-4100
Brand: TargetMol
SKU: T39913
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39913Cas No. 2367619-63-2

Alias TMX4100

TMX-4100, a selective phosphodiesterase 6D (PDE6D) degrader, demonstrates high degradation preference (DC50 <200 nM) in MOLT4, Jurkat, and MM.1S cells. This compound can be used for multiple myeloma research.

TMX-4100

🥰Excellent

Purity: 99.10%

Catalog No. T39913Alias TMX4100Cas No. 2367619-63-2

Pack Size	Price	Availability
1 mg	$100	In Stock
5 mg	$247	In Stock
10 mg	$396	In Stock
25 mg	$728	In Stock
50 mg	$987	In Stock
100 mg	$1,390	In Stock
200 mg	$1,870	In Stock
1 mL x 10 mM (in DMSO)	$272	In Stock

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Batch Information

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Purity:99.10%

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COA HNMR LCMS

Product Introduction

Bioactivity

Description	TMX-4100, a selective phosphodiesterase 6D (PDE6D) degrader, demonstrates high degradation preference (DC50 <200 nM) in MOLT4, Jurkat, and MM.1S cells. This compound can be used for multiple myeloma research.
In vitro	Methods: MOLT4, Jurkat, and MM.1S cells were treated with TMX-4100 (40nM, 200nM, 1μM), and the expression of target proteins was detected by Western blotting. Results: TMX-4100 maintained its high degradation preference for PDE6D in MOLT4, Jurkat, and MM.1S cells, with DC50 values less than 200 nM after 4 hours of treatment at doses up to 1 μM. [1]
Synonyms	TMX4100

Chemical Properties

Molecular Weight	262.29
Formula	C₁₁H₁₀N₄O₂S
Cas No.	2367619-63-2
Smiles	O=C1NC(=O)C(N2N=NC(=C2)C3=CSC=C3)CC1
Relative Density.	1.65 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (305.01 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8126 mL	19.0629 mL	38.1257 mL	190.6287 mL
5 mM	0.7625 mL	3.8126 mL	7.6251 mL	38.1257 mL
10 mM	0.3813 mL	1.9063 mL	3.8126 mL	19.0629 mL
20 mM	0.1906 mL	0.9531 mL	1.9063 mL	9.5314 mL
50 mM	0.0763 mL	0.3813 mL	0.7625 mL	3.8126 mL
100 mM	0.0381 mL	0.1906 mL	0.3813 mL	1.9063 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc