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TMX-4100

Name: TMX-4100
Brand: TargetMol
SKU: T39913
Price: 100 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T39913Cas No. 2367619-63-2

Alias TMX4100

TMX-4100, a selective phosphodiesterase 6D (PDE6D) degrader, demonstrates high degradation preference (DC50 <200 nM) in MOLT4, Jurkat, and MM.1S cells. This compound can be used for multiple myeloma research.

TMX-4100

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Purity: 99.10%

Catalog No. T39913Alias TMX4100Cas No. 2367619-63-2

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$100	-	In Stock
5 mg	$247	-	In Stock
10 mg	$396	-	In Stock
25 mg	$728	-	In Stock
50 mg	$987	-	In Stock
100 mg	$1,390	-	In Stock
200 mg	$1,870	-	In Stock
1 mL x 10 mM (in DMSO)	$272	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.10%

Appearance:Solid

Color:White

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	TMX-4100, a selective phosphodiesterase 6D (PDE6D) degrader, demonstrates high degradation preference (DC50 <200 nM) in MOLT4, Jurkat, and MM.1S cells. This compound can be used for multiple myeloma research.
In vitro	Methods: MOLT4, Jurkat, and MM.1S cells were treated with TMX-4100 (40nM, 200nM, 1μM), and the expression of target proteins was detected by Western blotting. Results: TMX-4100 maintained its high degradation preference for PDE6D in MOLT4, Jurkat, and MM.1S cells, with DC50 values less than 200 nM after 4 hours of treatment at doses up to 1 μM. [1]
Synonyms	TMX4100

Chemical Properties

Molecular Weight	262.29
Formula	C₁₁H₁₀N₄O₂S
Cas No.	2367619-63-2
Smiles	O=C1NC(=O)C(N2N=NC(=C2)C3=CSC=C3)CC1
Relative Density.	1.65 g/cm3 (Predicted)

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (305.01 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 1 mg/mL (3.81 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	3.8126 mL	19.0629 mL	38.1257 mL	190.6287 mL
5 mM	0.7625 mL	3.8126 mL	7.6251 mL	38.1257 mL
10 mM	0.3813 mL	1.9063 mL	3.8126 mL	19.0629 mL
20 mM	0.1906 mL	0.9531 mL	1.9063 mL	9.5314 mL
50 mM	0.0763 mL	0.3813 mL	0.7625 mL	3.8126 mL
100 mM	0.0381 mL	0.1906 mL	0.3813 mL	1.9063 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc