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METTL16-IN-1 is a potent inhibitor of METTL16, with an IC50 value of 1.7 μM and a Kd value of 1.35 μM. It effectively suppresses the binding of U6 snRNA deletion to the METTL16 MTD, with an IC50 value of 2.5 μM. METTL16-IN-1 also exhibits antitumor activity.
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| Description | METTL16-IN-1 is a potent inhibitor of METTL16, with an IC50 value of 1.7 μM and a Kd value of 1.35 μM. It effectively suppresses the binding of U6 snRNA deletion to the METTL16 MTD, with an IC50 value of 2.5 μM. METTL16-IN-1 also exhibits antitumor activity. |
| In vitro | METTL16-IN-1 (Compound 45), at concentrations ranging from 12.5 to 50 μM over a period of 24 hours, enhances splicing of MAT2A and elevates total m6A mRNA levels in MDA-MB-231 and A549 cells. |
| Formula | C19H12BrN3O6S2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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