Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MAO-B-IN-21 is an MAO-B inhibitor characterized by superior antioxidant and anti-Aβ aggregation activities. The compound additionally shows metal-ion chelating capabilities, mitigates neuroinflammation (NO, TNF-α), and demonstrates neuroprotective effects with notable BBB permeability. In an Aβ1-42 induced Alzheimer's disease mouse model, MAO-B-IN-21 markedly enhances memory and cognitive functions [1].
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
25 mg | 6-8 weeks | $ 1,520.00 | |
50 mg | 6-8 weeks | $ 1,980.00 | |
100 mg | 6-8 weeks | $ 2,500.00 |
Description | MAO-B-IN-21 is an MAO-B inhibitor characterized by superior antioxidant and anti-Aβ aggregation activities. The compound additionally shows metal-ion chelating capabilities, mitigates neuroinflammation (NO, TNF-α), and demonstrates neuroprotective effects with notable BBB permeability. In an Aβ1-42 induced Alzheimer's disease mouse model, MAO-B-IN-21 markedly enhances memory and cognitive functions [1]. |
In vitro | MAO-B-IN-21 at a concentration of 37.5 μM in a methanol solution (甲醇溶液) inhibits Cu2+-induced ROS production due to its metal chelating properties and/or its antioxidant capacity, capable of scavenging free radicals from the Cu2+-ascorbic acid redox system [1]. Additionally, MAO-B-IN-21 at 25 μM for 24 hours at 37℃ suppresses the self-induced aggregation of Aβ1-42 and disassembles preformed Aβ1-42 fibrils [1]. Furthermore, MAO-B-IN-21 in a range of 2.5-25 μM over 24 hours inhibits the production of ROS in LPS-stimulated BV-2 microglial cells [1]. |
In vivo | MAO-B-IN-21 (30 mg/kg; ig; single dose) readily crosses the blood-brain barrier in Balb/C mice [1]. At doses of 8 mg/kg and 32 mg/kg administered intragastrically (ig; as a single dose), it reduces escape latency time (ELT) and decreases Aβ 1-42 levels, suggesting improvements in learning and memory in an Aβ-induced Alzheimer's disease (AD) mouse model [1]. Pharmacokinetic analysis in Balb/C mice [1] shows the following parameters: Tissue T 1/2 T max C max AUC 0-t AUC brain/plasma ratio with plasma at 1.15 h, 0.5 h, 1539 ng/mL, 2941 ng·h/mL, 0.69 and brain at 2.07 h, 1.0 h, 922.7 ng/g, and 2032.5 ng·h/g, respectively. |
Molecular Weight | 440.92 |
Formula | C24H25ClN2O4 |
CAS No. | 2956426-18-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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MAO-B-IN-21 2956426-18-7 Neuroscience Monoamine Oxidase inhibitor inhibit