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Anti-Phospho-TFEB (Ser142) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TFEB (Ser142). Anti-Phospho-TFEB (Ser142) Polyclonal Antibody can be used in WB.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
50 μL | $220 | 7-10 days | |
100 μL | $372 | 7-10 days | |
200 μL | $529 | 7-10 days |
Description | Anti-Phospho-TFEB (Ser142) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TFEB (Ser142). Anti-Phospho-TFEB (Ser142) Polyclonal Antibody can be used in WB. |
Synonyms | Transcription factor EB, TFEB (p-Ser142), TFEB (p-S142), TFEB, TCFEB, T-cell transcription factor EB, p-TFEB (Ser142), p-TFEB (S142), bHLHe35, alphaTFEB, alpha TFEB |
Ig Type | IgG |
Reactivity | Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse,Rabbit) |
Verified Activity | 1. Sample: LympHnode (Mouse) Lysate at 40 μg Primary: Anti-Phospho-TFEb (Ser142) (TMAB-01522) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kDa Observed band size: 52 kDa 2. Sample: Pancreas (Mouse) Lysate at 40 μg Primary: Anti-Phospho-TFEb (Ser142) (TMAB-01522) at 1/1000 dilution Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution Predicted band size: 52 kDa Observed band size: 52 kDa |
Application | |
Recommended Dose | WB: 1:500-2000 |
Antibody Type | Polyclonal |
Host Species | Rabbit |
Subcellular Localization | Cytoplasm. Nucleus. Note=Mainly present in the cytoplasm. Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus. |
Construction | Polyclonal Antibody |
Purification | Protein A purified |
Appearance | Liquid |
Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
Concentration | 1 mg/mL |
Research Background | Transcription factors of the basic helix-loop-helix zipper (bHLH-ZIP) family contain a basic domain, used for DNA binding, and HLH and ZIP domains, both used for oligomerization. TFEB was isolated from a human B-cell cDNA library using a binding sequence from the adenovirus major late promoter. This transcription factor probably binds to the USF/MLTF site and probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer. |
Immunogen | KLH conjugated Synthesised phosphopeptide: human TFEB around the phosphorylation site of Ser142 |
Antigen Species | Human |
Gene Name | TFEB |
Gene ID | |
Protein Name | Transcription factor EB |
Uniprot ID | |
Biology Area | HLH / Leucine Zipper,HLH / Leucine Zipper,Transcription Factors,Tumor Associated |
Function | Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta. |
Molecular Weight | Theoretical: 52 kDa. |
Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
Transport | Shipping with blue ice. |
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