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Anti-Phospho-TFEB (Ser142) Polyclonal Antibody

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Catalog No. TMAB-01522
Alias Transcription factor EB, TFEB (p-Ser142), TFEB (p-S142), TFEB, TCFEB, T-cell transcription factor EB, p-TFEB (Ser142), p-TFEB (S142), bHLHe35, alphaTFEB, alpha TFEB

Anti-Phospho-TFEB (Ser142) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TFEB (Ser142). Anti-Phospho-TFEB (Ser142) Polyclonal Antibody can be used in WB.

Anti-Phospho-TFEB (Ser142) Polyclonal Antibody

Anti-Phospho-TFEB (Ser142) Polyclonal Antibody

😃Good
Catalog No. TMAB-01522Alias Transcription factor EB, TFEB (p-Ser142), TFEB (p-S142), TFEB, TCFEB, T-cell transcription factor EB, p-TFEB (Ser142), p-TFEB (S142), bHLHe35, alphaTFEB, alpha TFEB
Anti-Phospho-TFEB (Ser142) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TFEB (Ser142). Anti-Phospho-TFEB (Ser142) Polyclonal Antibody can be used in WB.
Pack SizePriceAvailabilityQuantity
50 μL$2207-10 days
100 μL$3727-10 days
200 μL$5297-10 days
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Product Introduction

Bioactivity
Description
Anti-Phospho-TFEB (Ser142) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TFEB (Ser142). Anti-Phospho-TFEB (Ser142) Polyclonal Antibody can be used in WB.
SynonymsTranscription factor EB, TFEB (p-Ser142), TFEB (p-S142), TFEB, TCFEB, T-cell transcription factor EB, p-TFEB (Ser142), p-TFEB (S142), bHLHe35, alphaTFEB, alpha TFEB
Ig Type
IgG
Reactivity
Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse,Rabbit)
Verified Activity
1. Sample:
LympHnode (Mouse) Lysate at 40 μg
Primary: Anti-Phospho-TFEb (Ser142) (TMAB-01522) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52 kDa
Observed band size: 52 kDa
2. Sample:
Pancreas (Mouse) Lysate at 40 μg
Primary: Anti-Phospho-TFEb (Ser142) (TMAB-01522) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52 kDa
Observed band size: 52 kDa
Application
Recommended Dose
WB: 1:500-2000
Antibody Type
Polyclonal
Host SpeciesRabbit
Subcellular LocalizationCytoplasm. Nucleus. Note=Mainly present in the cytoplasm. Under aberrant lysosomal storage conditions, it translocates from the cytoplasm to the nucleus.
ConstructionPolyclonal Antibody
PurificationProtein A purified
AppearanceLiquid
Formulation0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Concentration1 mg/mL
Research BackgroundTranscription factors of the basic helix-loop-helix zipper (bHLH-ZIP) family contain a basic domain, used for DNA binding, and HLH and ZIP domains, both used for oligomerization. TFEB was isolated from a human B-cell cDNA library using a binding sequence from the adenovirus major late promoter. This transcription factor probably binds to the USF/MLTF site and probably recognizes E-box sequences in the heavy-chain immunoglobulin enhancer.
Antigen Details
Immunogen
KLH conjugated Synthesised phosphopeptide: human TFEB around the phosphorylation site of Ser142
Antigen Species
Human
Gene Name
TFEB
Gene ID
Protein Name
Transcription factor EB
Uniprot ID
Biology Area
HLH / Leucine Zipper,HLH / Leucine Zipper,Transcription Factors,Tumor Associated
Function
Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.
Chemical Properties
Molecular WeightTheoretical: 52 kDa.
Stability & Storage
Stability & StorageStore at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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