Anti-Phospho-TFEB(Ser142) Polyclonal Antibody

Anti-Phospho-TFEB(Ser142) Polyclonal Antibody is a Rabbit antibody targeting Phospho-TFEB(Ser142). Anti-Phospho-TFEB(Ser142) Polyclonal Antibody can be used in WB,IHC-P,IHC-Fr,ICC/IF,IF.

IgG

Mouse (predicted:Human,Rat,Dog,Pig,Cow,Horse,Rabbit)

Sample: Pancreas (Mouse) Lysate at 40 μg
Primary: Anti-Phospho-TFEb (Ser142) (TMAB-11370) at 1/1000 dilution
Secondary: IRDye800CW Goat Anti-Rabbit IgG at 1/20000 dilution
Predicted band size: 52 kD
Observed band size: 52 kD

WB: 1:500-2000; IHC-P: 1:100-500; IHC-Fr: 1:100-500; ICC/IF: 1:100-500; IF: 1:100-500

Polyclonal

KLH conjugated Synthesised phosphopeptide: human TFEB around the phosphorylation site of Ser142

Human

TFEB

Transcription factor EB

Transcription factor that specifically recognizes and binds E-box sequences (3'-CANNTG-5'). Efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFE3 or MITF. In association with TFE3, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity. Specifically recognizes and binds the CLEAR-box sequence (5'-GTCACGTGAC-3') present in the regulatory region of many lysosomal genes, leading to activate their expression. It thereby plays a central role in expression of lysosomal genes. Specifically recognizes the gamma-E3 box, a subset of E-boxes, present in the heavy-chain immunoglobulin enhancer. Plays a role in the signal transduction processes required for normal vascularization of the placenta.