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Anti-Phospho-CHEK1 (Ser286) Polyclonal Antibody
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Catalog No. TMAC-00834
Anti-Phospho-CHEK1 (Ser286) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CHEK1 (Ser286). Anti-Phospho-CHEK1 (Ser286) Polyclonal Antibody can be used in WB,IF,ELISA.
Anti-Phospho-CHEK1 (Ser286) Polyclonal Antibody
Anti-Phospho-CHEK1 (Ser286) Polyclonal Antibody
😃Good
Catalog No. TMAC-00834
Anti-Phospho-CHEK1 (Ser286) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CHEK1 (Ser286). Anti-Phospho-CHEK1 (Ser286) Polyclonal Antibody can be used in WB,IF,ELISA.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 50 μL | $218 | 7-10 days | |
| 100 μL | $317 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Phospho-CHEK1 (Ser286) Polyclonal Antibody is a Rabbit antibody targeting Phospho-CHEK1 (Ser286). Anti-Phospho-CHEK1 (Ser286) Polyclonal Antibody can be used in WB,IF,ELISA. |
| Ig Type | IgG |
| Reactivity | Human,Mouse,Rat |
| Application | |
| Recommended Dose | WB: 1:500-2000; IF: 1:200-1000; ELISA: 1:5000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Construction | Polyclonal Antibody |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Appearance | Liquid |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| Research Background | Required for checkpoint mediated cell cycle arrest in response to DNA damage or the presence of unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles. Recognizes the substrate consensus sequence [R-X-X-S/T]. Binds to and phosphorylates CDC25A, CDC25B and CDC25C. Phosphorylation of CDC25A at 'Ser-178' and 'Thr-507' and phosphorylation of CDC25C at 'Ser-216' creates binding sites for 14-3-3 proteins which inhibit CDC25A and CDC25C. Phosphorylation of CDC25A at 'Ser-76', 'Ser-124', 'Ser-178', 'Ser-279' and 'Ser-293' promotes proteolysis of CDC25A. Inhibition of CDC25 activity leads to increased inhibitory tyrosine phosphorylation of CDK-cyclin complexes and blocks cell cycle progression. Binds to and phosphorylates RAD51 at 'Thr-309', which may enhance the association of RAD51 with chromatin and promote DNA repair by homologous recombination. Binds to and phosphorylates TLK1 at 'Ser-743', which prevents the TLK1-dependent phosphorylation of the chromatin assembly factor ASF1A. This may affect chromatin assembly during S phase or DNA repair. May also phosphorylate multiple sites within the C-terminus of TP53, which promotes activation of TP53 by acetylation and enhances suppression of cellular proliferation. |
| Conjucates | Unconjugated |
| Others Formats | Phospho |
| Immunogen | A synthesized phosphopeptide: human Chk1 around the phosphorylation site of Ser286. AA range:256-305 |
| Antigen Species | human |
| Uniprot ID |
| Molecular Weight | Actual: 55 kDa. |
Stability & Storage
| Stability & Storage | Store at -15°C to -25°C for 12 months (Do not lower than -25°C). Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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