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Anti-IGF1R/CD221 Antibody

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Catalog No. T9901A-1374

Anti-IGF1R/CD221 Antibody is a highly specific monoclonal antibody targeting the Type I Insulin-like Growth Factor Receptor (IGF-1R/CD221). By binding to the extracellular domain of IGF-1R, this antibody effectively blocks the interaction with its ligands IGF-1 and IGF-2, thereby inhibiting the activation of downstream PI3K/Akt and MAPK signaling pathways. It is a vital tool for researching tumor cell growth inhibition, apoptosis induction, and transmembrane signaling mechanisms.

Anti-IGF1R/CD221 Antibody

Anti-IGF1R/CD221 Antibody

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Catalog No. T9901A-1374
Anti-IGF1R/CD221 Antibody is a highly specific monoclonal antibody targeting the Type I Insulin-like Growth Factor Receptor (IGF-1R/CD221). By binding to the extracellular domain of IGF-1R, this antibody effectively blocks the interaction with its ligands IGF-1 and IGF-2, thereby inhibiting the activation of downstream PI3K/Akt and MAPK signaling pathways. It is a vital tool for researching tumor cell growth inhibition, apoptosis induction, and transmembrane signaling mechanisms.
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Product Introduction

Bioactivity
Description
Anti-IGF1R/CD221 Antibody is a highly specific monoclonal antibody targeting the Type I Insulin-like Growth Factor Receptor (IGF-1R/CD221). By binding to the extracellular domain of IGF-1R, this antibody effectively blocks the interaction with its ligands IGF-1 and IGF-2, thereby inhibiting the activation of downstream PI3K/Akt and MAPK signaling pathways. It is a vital tool for researching tumor cell growth inhibition, apoptosis induction, and transmembrane signaling mechanisms.
In vitro
In cell-based assays, Anti-IGF1R/CD221 Antibody significantly inhibits IGF-1-induced receptor autophosphorylation and suppresses the proliferation of various human cancer cell lines, including breast and lung cancer [1].
In vivo
Systemic administration of the Anti-IGF1R/CD221 Antibody in tumor xenograft models leads to a marked reduction in tumor volume and induces a significant increase in cancer cell apoptosis [1].
Reactivity
Human
Application
FACS
Functional assay
Antibody Type
Monoclonal
FormulationSupplied as a sterile solution in a buffered formulation system (e.g., phosphate-, citrate-, or amino acid-based). Please refer to the CoA for lot-specific composition.
Endotoxin<1.0 EU/mg
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Uniprot ID
TargetIGF-1R/CD221
Chemical Properties
Antibody Information
IsotypeIgG1
Storage & Solubility Information
Storagestore at low temperature | -20°C for 2 years, 4°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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