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OPC-14523 hydrochloride

Name: OPC-14523 hydrochloride
Brand: TargetMol
SKU: T62711
Rating: 4.5 (1 reviews)

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Catalog No. T62711Cas No. 145969-31-9

Alias VPI 013 hydrochloride

OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist with antidepressant-like activity, showing high affinity for the sigma receptor σ1/2 (IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM).

OPC-14523 hydrochloride

😃Good

Purity: 99.60%

Catalog No. T62711Alias VPI 013 hydrochlorideCas No. 145969-31-9

Pack Size	Price	USA Warehouse	Global Warehouse
5 mg	$970	6-8 weeks	6-8 weeks
10 mg	$1,289	6-8 weeks	6-8 weeks
25 mg	$1,619	6-8 weeks	6-8 weeks
50 mg	$1,980	6-8 weeks	6-8 weeks
100 mg	$2,500	6-8 weeks	6-8 weeks
1 mL x 10 mM (in DMSO)	$1,028	6-8 weeks	6-8 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.60%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	OPC-14523 hydrochloride is an orally active sigma and 5-HT1A receptor agonist with antidepressant-like activity, showing high affinity for the sigma receptor σ1/2 (IC50=47/56 nM), the 5-HT1A receptor (IC50=2.3 nM), and the 5-HT transporter (IC50=80 nM).
Targets&IC50	[3H]-5-HT:27 nM, 5-HT1A Receptor:2.3 nM, σ1 receptor:47 nM, σ2 receptor:56 mM
In vitro	OPC-14523 inhibits the in vitro reuptake of 3H-5-HT (IC50 = 27 nM), but exhibits very weak inhibition activity against the reuptake of 3H-NE and 3H-DA. OPC-14523 does not inhibit activity at the A or B receptors or muscarinic receptors.
In vivo	In Wistar rats (140-245 g), OPC-14523 hydrochloride (0.3-100 mg/kg; orally; daily for 0, 2, 4, 7 days) reduces immobility time in the depression experiment[1].
Synonyms	VPI 013 hydrochloride

Chemical Properties

Molecular Weight	450.4
Formula	C₂₃H₂₉Cl₂N₃O₂
Cas No.	145969-31-9
Smiles	Cl.COc1cccc2N(CCCN3CCN(CC3)c3cccc(Cl)c3)C(=O)CCc12
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (133.21 mM), Sonification is recommended.

H2O: 3 mg/mL (6.66 mM), Sonification is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 2.5 mg/mL (5.55 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.2202 mL	11.1012 mL	22.2025 mL	111.0124 mL
5 mM	0.4440 mL	2.2202 mL	4.4405 mL	22.2025 mL

DMSO

	1mg	5mg	10mg	50mg
10 mM	0.2220 mL	1.1101 mL	2.2202 mL	11.1012 mL
20 mM	0.1110 mL	0.5551 mL	1.1101 mL	5.5506 mL
50 mM	0.0444 mL	0.2220 mL	0.4440 mL	2.2202 mL
100 mM	0.0222 mL	0.1110 mL	0.2220 mL	1.1101 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc