L-Lysine-13C6-15N2 Hydrochloride is L-Lysine hydrochloride labeled with 13C and 15N isotopes. L-Lysine hydrochloride is an essential amino acid for humans and a common food additive. It stimulates the secretion of pepsin and gastric acid, enhances gastric juice secretion, and promotes growth and development in children.

Phenol-13C6 is a 13C-labeled Phenol, which is an important chemical raw material used in the manufacture of fungicides and herbicides.

D-Fructose-13C6 can be used as an internal standard for the quantification of D-fructose by GC- or LC-MS.

L-Leucine-1-13C (L-Leucine-13C) is a 13C-labeled L-Leucine that significantly enhances the affinity of GLP-4.

Vancomycin-C13,D3 is a compound labeled with 13C and 2H. Vancomycin is a glycopeptide antibiotic that exerts antibacterial activity by altering cell membrane permeability and selectively inhibiting RNA synthesis.

Apalutamide-13C-d3 (RN-509-13C,d3) is a 13C and 2H-labeled version of Apalutamide. Apalutamide is an efficient androgen receptor (AR) antagonist used in the study of prostate diseases.

Riluzole-13C,15N2 (PK 26124-13C,15N2) is a 13C and 15N labeled form of Riluzole. Riluzole is a glutamate antagonist with anticonvulsant activity, inhibiting GABA reuptake and used in ALS research.

Binimetinib-13C-d3 (MEK162-13C-d3) is an isotopically labelled compound of Binimetinib for use as a tracer.Binimetinib (ARRY-162) is a selective MEK1/2 inhibitor for the treatment of melanoma.

Apixaban 13C,d3 is a deuterium labeling of Apixaban for isotopic tracing. Apixaban 13C,d3 is a selective inhibitor of coagulation factor Xa and is used in thromboembolism studies

Cyanuric acid-13C3 is a 13C-labelled compound of cyanuric acid, which can be used for isotope tracing. Cyanuric acid is a triazine compound, fungicide, and herbicide.

4-Trifluoromethylsalicylic acid-13C6 is 13C-labeled 4-Trifluoromethylsalicylic acid, mainly used as a quantitative tracer in drug development. 4-Trifluoromethylsalicylic acid is also a platelet aggregation inhibitor.

2-Nitrobenzaldehyde semicarbazone (13C, 15N2) is utilized in the LC-MS/MS method for semicarbazide analysis.

1,2-Dioleoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2-dioleoyl-rac-glycerol by GC- or LC-MS. 1,2-dioleoyl-rac-glycerol is a diacylglycerol that contains oleic acid at the sn-1 and sn-2 positions. It effectively binds the C1 domain to activate conventional protein kinase C forms and serves as a substrate for diacylglycerol kinases and multisubstrate lipid kinase.1,2,3 |1. Yamaguchi, Y., Shirai, Y., Matsubara, T., et al. Phosphorylation and up-regulation of diacylglycerol kinase γ via its interaction with protein kinase Cγ. J. Biol. Chem. 281(42), 31627-31637 (2006).|2. Zhou, Q.Z., Raynor, R.L., Wood, M.G., Jr., et al. Structure-activity relationship of synthetic branched-chain distearoylglycerol (distearin) as protein kinase C activators. Biochemistry 27(19), 7361-7365 (1988).|3. Epand, R.M., Shulga, Y.V., Timmons, H.C., et al. Substrate chirality and specificity of diacylglycerol kinases and the multisubstrate lipid kinase. Biochemistry 46(49), 14225-14231 (2007).

Nitisinone-13C6is intended for use as an internal standard for the quantification of nitisinone by GC- or LC-MS. Nitisinone is an inhibitor of 4-hydroxyphenylpyruvate dioxygenase (HPPD), which converts 4-hydroxyphenylpyruvate (HPPA) to homogentisate in the tyrosine catabolic pathway.1Nitisinone increases urinary levels of HPPA and 4-hydroxyphenyllactate (HPLA) in rats when administered at a dose of 10 mg/kg. Nitisinone (3 mg/kg) prevents the neonatal lethality of fumarylacetoacetate hydrolase (FAH) deficiency in mice when administered to pregnant dams.2It exhibits hepatoprotective effects inFAH-/-mice, such as prevention of increases in plasma levels of aspartate serine aminotransferase (AST) and conjugated bilirubin, when administration is continued following birth at a dose of 1 mg/kg. Nitisinone (100 μg) decreases urinary excretion of homogentisate and increases urinary excretion of HPPA, HPLA, and 4-hydroxyphenylacetate in a mouse model of alkaptonuria induced by ethylnitrosourea.3Formulations containing nitisinone have been used in the treatment of hereditary tyrosinemia type 1 (HT-1). 1.Ellis, M.K., Whitfield, A.C., Gowans, L.A., et al.Inhibition of 4-hydroxyphenylpyruvate dioxygenase by 2-(2-nitro-4-trifluoromethylbenzoyl)-cyclohexane-1,3-dione and 2-(2-chloro-4-methanesulfonylbenzoyl)-cyclohexane-1,3-dioneToxicol. Appl. Pharmacol.133(1)12-19(1995) 2.Grompe, M., Lindstedt, S., al-Dhalimy, M., et al.Pharmacological correction of neonatal lethal hepatic dysfunction in a murine model of hereditary tyrosinaemia type INat. Genet.10(4)453-460(1995) 3.Suzuki, Y., Oda, K., Yoshikawa, Y., et al.A novel therapeutic trial of homogentisic aciduria in a murine model of alkaptonuriaJ. Hum. Genet.44(2)79-84(1999)

Cefotaxime-d3 is the deuterium-labeled form of Cefotaxime. Cefotaxime is a cephalosporin stable against β-lactamase, classified as a third-generation cephalosporin antibiotic. It exhibits broad-spectrum antibacterial activity against a variety of Gram-positive and Gram-negative bacteria.

Moxifloxacin-d4 hydrochloride (BAY 12-8039-d4) is the hydrochloride salt form of deuterium-labeled Moxifloxacin (Moxifloxacin). This compound acts as an orally effective antibacterial agent and is utilized in research concerning acute bacterial sinusitis, acute bacterial exacerbations of chronic bronchitis, and infectious pneumonia.

L-Homocysteine-d4 is the deuterium-labeled variant of L-Homocysteine.

1,2,3-Trioctanoyl-rac-glycerol-13C3 is intended for use as an internal standard for the quantification of 1,2,3-trioctanoyl-rac-glycerol by GC- or LC-MS. 1,2,3-Trioctanoyl-rac-glycerol is a triacylglycerol that contains octanoic acid at the sn-1, sn-2, and sn-3 positions. Dietary administration of 1,2,3-trioctanoyl-rac-glycerol increases hippocampal levels of the glycolytic metabolites glucose 6-phosphate, fructose 6-phosphate, and β-hydroxybutyrate and the seizure threshold in the 6 Hz psychomotor seizure test in mice.1 Formulations containing 1,2,3-trioctanoyl-rac-glycerol have been used in cosmetic products as thickening and skin-conditioning agents.

[11C]-MK-7337 is the 11C-labeled version of MK-7337. MK-7337 is a PET ligand for α-synuclein. The 11C-labeled MK-7337 can be used as a PET tracer for imaging of neurodegenerative diseases such as Parkinson's disease.

Cefazolin-13C2,15N is intended for use as an internal standard for the quantification of cefazolin by GC- or LC-MS. Cefazolin is a broad-spectrum cephalosporin antibiotic that is active in vitro against various Gram-positive and Gram-negative bacteria (MICs = 0.2-12.5 μg/ml). It also inhibits the growth of clinical isolates of S. aureus, E. coli, P. mirabilis, and K. pneumoniae (MICs = 0.1-25 μg/ml). In vivo, cefazolin protects against S. aureus, E. coli, and P. mirabilis infection in mice (ED50s = <0.09-1.78, 0.44-3.63, and 2.31-5.2 mg/animal, respectively). Formulations containing cefazolin have been used to treat a variety of bacterial infections.

Sacubitril-13C4 (hemicalcium salt) is the carbon-13 and deuterium-labeled version of Sacubitril hemicalcium salt. Sacubitril (AHU-377) hemicalcium salt is a potent NEP inhibitor with an IC50 value of 5 nM. It is a component of the active pharmaceutical compound LCZ696, used in heart failure research.

6-HydroxyChlorzoxazone-13C6 is a 13C-labeled compound of 6-HydroxyChlorzoxazone and can be used for isotope tracing.

Linoleic acid-13C1 is a 13C-labeled form of linoleic acid, a widely found polyunsaturated fatty acid (PUFA) present in plant oils, nuts, and seeds. As a component of membrane phospholipids, linoleic acid contributes to membrane fluidity and supports the transdermal water barrier of the epidermis. Its oxidation can lead to the damage of red blood cells and hemoglobin.

Creatine-13C is creatine labeled with 13C. Creatine, an endogenous amino acid metabolite, plays a crucial role in cellular energy, particularly in muscle and brain tissues.