Shopping Cart

Remove All
Your shopping cart is currently empty

LP-533401 hydrochloride

Name: LP-533401 hydrochloride
Brand: TargetMol
SKU: T15779
Price: 123 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T15779Cas No. 1040526-12-2

LP-533401 hydrochloride is a peripheral Tph inhibitor that cannot cross the blood-brain barrier
that inhibits 5-hydroxytryptamine synthesis and can be used to study periodontal disease and hepatic steatosis.

LP-533401 hydrochloride

🥰Excellent

Purity: 98%

Catalog No. T15779Cas No. 1040526-12-2

Pack Size	Price	Availability
1 mg	$34	In Stock
5 mg	$81	In Stock
10 mg	$123	In Stock
25 mg	Preferential	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

Add to Cart

Add to Quotation

Bulk & Custom

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Batch Information

Select Batch

Purity:98%

Resource Download

COA

Product Introduction

Bioactivity

Description	LP-533401 hydrochloride is a peripheral Tph inhibitor that cannot cross the blood-brain barrier that inhibits 5-hydroxytryptamine synthesis and can be used to study periodontal disease and hepatic steatosis.
In vitro	LP-533401 hydrochloride (0.1-1 μM; 3 days) completely inhibited serotonin production in RBL2H3 cells.
In vivo	LP-533401 hydrochloride (250, 100, 10 mg/kg) prevented and rescued ovariectomized mice from osteoporosis [1].

Chemical Properties

Molecular Weight	562.94
Formula	C₂₇H₂₃ClF₄N₄O₃
Cas No.	1040526-12-2
Smiles	Cl.N[C@@H](Cc1ccc(cc1)-c1cc(OC(c2ccc(cc2)-c2cccc(F)c2)C(F)(F)F)nc(N)n1)C(O)=O
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 15 mg/mL (26.65 mM), Sonification is recommended.

H2O: < 0.1 mg/mL (insoluble)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.7764 mL	8.8819 mL	17.7639 mL	88.8194 mL
5 mM	0.3553 mL	1.7764 mL	3.5528 mL	17.7639 mL
10 mM	0.1776 mL	0.8882 mL	1.7764 mL	8.8819 mL
20 mM	0.0888 mL	0.4441 mL	0.8882 mL	4.4410 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Sci Citations

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc