Powder: -20°C for 3 years | In solvent: -80°C for 1 year
T-91825 (PPI-0903M) is a potent N-phosphono-type cephalosporin compound, which serves as the active variant of TAK-599. It exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria [1][2].
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Description | T-91825 (PPI-0903M) is a potent N-phosphono-type cephalosporin compound, which serves as the active variant of TAK-599. It exhibits broad-spectrum activity against both gram-positive and gram-negative bacteria [1][2]. |
In vitro | PPI-0903M is very active against S. aureus (MIC50=0.25 μg/mL), including methicillin-resistant (MRSA) strains (MIC50=1 μg/mL)[1].PPI-0903M is active against hetero-vancomycin-intermediate S. aureus (100 strains), with MIC50s ranging from 0.25 to 4 μg/mL[1]. |
In vivo | AK-599, administered subcutaneously at a dosage of 20 mg/kg three times daily for a duration of 2 days, significantly reduces bacterial cell counts in the lungs by more than 99.9% in a mouse model of pneumonia induced by MRSA[2]. |
Molecular Weight | 604.69 |
Formula | C22H20N8O5S4 |
CAS No. | 189345-04-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (165.37 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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T-91825 189345-04-8 T91825 T 91825 inhibitor inhibit