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[D-Phe2,D-Ala6]-LH-RH

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Catalog No. T83498Cas No. 54784-44-0
Alias Wy 18185

[D-Phe2,D-Ala6]-LH-RH is a potent luteinizing hormone-releasing hormone (LH-RH) antagonist, exhibiting significant activity against LH/FSH-RH and possessing the ability to inhibit ovulation [1].

[D-Phe2,D-Ala6]-LH-RH

[D-Phe2,D-Ala6]-LH-RH

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Catalog No. T83498Alias Wy 18185Cas No. 54784-44-0
[D-Phe2,D-Ala6]-LH-RH is a potent luteinizing hormone-releasing hormone (LH-RH) antagonist, exhibiting significant activity against LH/FSH-RH and possessing the ability to inhibit ovulation [1].
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Product Introduction

Bioactivity
Description
[D-Phe2,D-Ala6]-LH-RH is a potent luteinizing hormone-releasing hormone (LH-RH) antagonist, exhibiting significant activity against LH/FSH-RH and possessing the ability to inhibit ovulation [1].
In vivo
[D-Phe2,D-Ala6]-LH-RH effectively suppresses the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) stimulated by LH-RH in immature male rats [1]. Administered subcutaneously at 1 mg/rat, the compound shows significant anti-ovulatory and contraceptive effects [2]. A single subcutaneous dose at varying concentrations (0.625, 1.25, 2.5 mg/kg) leads to a dose-dependent enhancement of LH-RH activity in the stalk-median eminence (SME) while reducing plasma LH-RH activity in 25-day-old hypophysectomized (hypox) rats [3]. A higher dose of 25 mg/kg, administered subcutaneously, effectively prevents ovulation induced by LRH [4].
SynonymsWy 18185
Chemical Properties
Molecular Weight1206.35
FormulaC59H79N15O13
Cas No.54784-44-0
SmilesC([C@H](NC([C@@H](CC1=CC=CC=C1)NC(=O)[C@H]2NC(=O)CC2)=O)C(N[C@H](C(N[C@@H](CC3=CC=C(O)C=C3)C(N[C@@H](C(N[C@H](C(N[C@H](C(=O)N4[C@H](C(NCC(N)=O)=O)CCC4)CCCNC(=N)N)=O)CC(C)C)=O)C)=O)=O)CO)=O)C=5C=6C(NC5)=CC=CC6
SequenceH-Pyr-D-Phe-Trp-Ser-Tyr-D-Ala-Leu-Arg-Pro-Gly-NH2
Sequence ShortXFWSYALRPG
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
TargetMol | Animal experiments For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent 10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.
Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSOTargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSOTargetMol | reagent stock solution to 400 μL PEG300TargetMol | reagent and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH2OTargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.
1 Enter information below:
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2 Enter the in vivo formulation:
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