keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
[D-Phe2,D-Ala6]-LH-RH is a potent luteinizing hormone-releasing hormone (LH-RH) antagonist with demonstrated activities against LH/FSH-RH and an ability to inhibit ovulation [1].
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Description | [D-Phe2,D-Ala6]-LH-RH is a potent luteinizing hormone-releasing hormone (LH-RH) antagonist with demonstrated activities against LH/FSH-RH and an ability to inhibit ovulation [1]. |
In vivo | [D-Phe2,D-Ala6]-LH-RH effectively suppresses the release of luteinizing hormone (LH) and follicle-stimulating hormone (FSH) stimulated by LH-RH in immature male rats [1]. Administered subcutaneously at a dose of 1 mg/rat, this compound demonstrates significant anti-ovulatory and contraceptive effects [2]. Moreover, a single subcutaneous dose of [D-Phe2,D-Ala6]-LH-RH at varying concentrations (0.625, 1.25, 2.5 mg/kg) leads to a dose-dependent enhancement of LH-RH activity in the stalk-median eminence (SME) while concurrently reducing plasma LH-RH activity in 25-day-old hypophysectomized (hypox) rats [3]. At a higher dose of 25 mg/kg, given subcutaneously, it effectively prevents ovulation that is typically induced by LRH [4]. |
Synonyms | Wy 18185 |
Molecular Weight | 1206.35 |
Formula | C59H79N15O13 |
CAS No. | 54784-44-0 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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[D-Phe2,D-Ala6]-LH-RH 54784-44-0 Wy 18185 inhibitor inhibit