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Lucitanib dihydrochloride

Name: Lucitanib dihydrochloride
Brand: TargetMol
SKU: T89507
Rating: 4.5 (1 reviews)

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Catalog No. T89507Cas No. 2108875-91-6

Alias E-3810 dihydrochloride, E3810 dihydrochloride, CO-3810 dihydrochloride, CO3810 dihydrochloride, AL3810 dihydrochloride, AL 3810 dihydrochloride

Lucitanib dihydrochloride (E-3810 dihydrochloride) is an efficient inhibitor of VEGFR1-3, FGFR1-3, and PDGFRalpha/β, useful in metastatic breast cancer research.

Lucitanib dihydrochloride

😃Good

Catalog No. T89507Alias E-3810 dihydrochloride, E3810 dihydrochloride, CO-3810 dihydrochloride, CO3810 dihydrochloride, AL3810 dihydrochloride, AL 3810 dihydrochlorideCas No. 2108875-91-6

Lucitanib dihydrochloride (E-3810 dihydrochloride) is an efficient inhibitor of VEGFR1-3, FGFR1-3, and PDGFRalpha/β, useful in metastatic breast cancer research.

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
10 mg	Inquiry	10-14 weeks	10-14 weeks
50 mg	Inquiry	10-14 weeks	10-14 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Lucitanib dihydrochloride (E-3810 dihydrochloride) is an efficient inhibitor of VEGFR1-3, FGFR1-3, and PDGFRalpha/β, useful in metastatic breast cancer research.
Targets&IC50	VEGFR1:7 nM, VEGFR2:25 nM, FGFR2:82.5 nM, FGFR1:17.5 nM, VEGFR3:10 nM
In vitro	Lucitanib dihydrochloride (E-3810 dihydrochloride) has potent inhibitory effects on VEGFR and FGFR autophosphorylation and can effectively inhibit VEGF- and bFGF-induced HUVEC proliferation with IC50 values of 40 and 50 nM, respectively. It can also inhibit CSF-1R with an IC50 value of 5 nM. [1]
In vivo	Lucitanib dihydrochloride (E-3810 dihydrochloride) (20 mg/kg, oral, 7 days) treated mice, Lucitanib completely inhibited the bFGF-induced angiogenic response. Methods: Lucitanib dihydrochloride (15 mg/kg, oral, 30 days) was treated in mice bearing the MDA-MB-231 advanced breast cancer model, and tumor size was evaluated in vivo. Results: Lucitanib dihydrochloride effectively stabilized tumor growth. [3]
Synonyms	E-3810 dihydrochloride, E3810 dihydrochloride, CO-3810 dihydrochloride, CO3810 dihydrochloride, AL3810 dihydrochloride, AL 3810 dihydrochloride

Chemical Properties

Molecular Weight	516.42
Formula	C₂₆H₂₇Cl₂N₃O₄
Cas No.	2108875-91-6
Smiles	O=C(C1=CC=CC2=CC(OC3=C4C=C(OC)C(OCC5(CC5)N)=CC4=NC=C3)=CC=C21)NC.Cl.Cl
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at -20°C | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 16 mg/mL (30.98 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.9364 mL	9.6820 mL	19.3641 mL	96.8204 mL
5 mM	0.3873 mL	1.9364 mL	3.8728 mL	19.3641 mL
10 mM	0.1936 mL	0.9682 mL	1.9364 mL	9.6820 mL
20 mM	0.0968 mL	0.4841 mL	0.9682 mL	4.8410 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc