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[Pyr1]-Apelin-13

Name: [Pyr1]-Apelin-13
Brand: TargetMol
SKU: TP1260
Price: 89 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. TP1260Cas No. 217082-60-5

Alias [pGlu1]-Apelin-13

[Pyr1]-Apelin-13 ([pGlu1]-Apelin-13) is a potent and selective endogenous Apelin receptor (APJ) agonist.

[Pyr1]-Apelin-13

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Purity: 99.71%

Catalog No. TP1260Alias [pGlu1]-Apelin-13Cas No. 217082-60-5

[Pyr1]-Apelin-13 ([pGlu1]-Apelin-13) is a potent and selective endogenous Apelin receptor (APJ) agonist.

Pack Size	Price	Availability
1 mg	$89	In Stock
5 mg	$248	In Stock
10 mg	$389	In Stock
25 mg	$642	In Stock
50 mg	$883	In Stock
100 mg	$1,190	In Stock
200 mg	$1,630	In Stock

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Purity:99.71%

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COA LCMS

Product Introduction

Bioactivity

Description	[Pyr1]-Apelin-13 ([pGlu1]-Apelin-13) is a potent and selective endogenous Apelin receptor (APJ) agonist.
In vitro	Encapsulation of [Pyr1]-apelin-13 in lipoPEG particles (lipoPEG-PA13) enables sustained and extended drug release in both in vitro and in vivo conditions[1].
In vivo	In a study involving a mouse model of pressure-overload induced heart failure, nanocarriers containing [Pyr1]-apelin-13 demonstrated a prolonged effect in preventing cardiac dysfunction, highlighting its potential therapeutic benefits. Additionally, [Pyr1] apelin-13 at doses of 1 and 5 μg was found to enhance locomotor activity, alleviate pain symptoms, decrease cavity size, and reduce caspase-3 levels in rats, indicating its analgesic and anti-inflammatory properties. Furthermore, the compound significantly increased thermal paw withdrawal latency and, at a 5 μg dose, notably improved paw withdrawal threshold in comparison to spinal cord injury (SCI) animals from the second week post-SCI, suggesting its effectiveness in pain management and functional recovery post-SCI.
Synonyms	[pGlu1]-Apelin-13

Chemical Properties

Molecular Weight	1533.8
Formula	C₆₉H₁₀₈N₂₂O₁₆S
Cas No.	217082-60-5
Smiles	CSCC[C@H](NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(N)=N)NC[C@@H]1CCCN1)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(O)=O
Relative Density.	1.51 g/cm3 (Predicted)
Sequence	{Glp}-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
Sequence Short	{Glp}-RPRLSHKGPMPF

Storage & Solubility Information

Storage

keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 50 mg/mL (32.6 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	0.6520 mL	3.2599 mL	6.5198 mL	32.5988 mL
5 mM	0.1304 mL	0.6520 mL	1.3040 mL	6.5198 mL
10 mM	0.0652 mL	0.3260 mL	0.6520 mL	3.2599 mL
20 mM	0.0326 mL	0.1630 mL	0.3260 mL	1.6299 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

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