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TP0427736 hydrochloride is a novel and selective ALK5 inhibitor with an IC50 of 2.72 nM, capable of inhibiting Smad2/3 phosphorylation in A549 cells, reducing TGF-β-induced growth inhibition of human root sheath cells, and prolonging the anagen phase of mouse hair follicles.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $37 | In Stock | |
5 mg | $85 | In Stock | |
10 mg | $137 | In Stock | |
25 mg | $259 | In Stock | |
50 mg | $416 | In Stock | |
100 mg | $678 | In Stock | |
200 mg | $943 | In Stock |
Description | TP0427736 hydrochloride is a novel and selective ALK5 inhibitor with an IC50 of 2.72 nM, capable of inhibiting Smad2/3 phosphorylation in A549 cells, reducing TGF-β-induced growth inhibition of human root sheath cells, and prolonging the anagen phase of mouse hair follicles. |
In vitro | Method: 3T3-L1 cells overexpressing BMP8B were treated with TP0427736 hydrochloride (5 μM), and the effect on intracellular lipid levels was observed.
Result: TP0427736 hydrochloride effectively prevented the reduction of lipids in LV-Bmp8b cells. [1] |
Alias | TP 0427736 hydrochloride |
Molecular Weight | 334.85 |
Formula | C14H11ClN4S2 |
Cas No. | 2459963-17-6 |
Smiles | Cl.N1=CSC=2C=C(C=CC12)C=3NC=NC3C4=NC(=CS4)C |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
Solubility Information | DMSO: 1 mg/mL (2.99 mM), Sonication is recommended. H2O: 2 mg/mL (5.97 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO/H2O
H2O
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