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TP0427736 hydrochloride
🥰Excellent
Catalog No. T61029Cas No. 2459963-17-6
Alias TP 0427736 hydrochloride
TP0427736 hydrochloride is a novel and selective ALK5 inhibitor with an IC50 of 2.72 nM, capable of inhibiting Smad2/3 phosphorylation in A549 cells, reducing TGF-β-induced growth inhibition of human root sheath cells, and prolonging the anagen phase of mouse hair follicles.
TP0427736 hydrochloride
🥰Excellent
Purity: 98.99%
Catalog No. T61029Alias TP 0427736 hydrochlorideCas No. 2459963-17-6
TP0427736 hydrochloride is a novel and selective ALK5 inhibitor with an IC50 of 2.72 nM, capable of inhibiting Smad2/3 phosphorylation in A549 cells, reducing TGF-β-induced growth inhibition of human root sheath cells, and prolonging the anagen phase of mouse hair follicles.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 1 mg | $35 | - | In Stock | |
| 5 mg | $81 | - | In Stock | |
| 10 mg | $129 | - | In Stock | |
| 25 mg | $247 | - | In Stock | |
| 50 mg | $396 | - | In Stock | |
| 100 mg | $645 | - | In Stock | |
| 200 mg | $887 | - | In Stock |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:98.99%
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Product Introduction
Bioactivity
Chemical Properties
| Description | TP0427736 hydrochloride is a novel and selective ALK5 inhibitor with an IC50 of 2.72 nM, capable of inhibiting Smad2/3 phosphorylation in A549 cells, reducing TGF-β-induced growth inhibition of human root sheath cells, and prolonging the anagen phase of mouse hair follicles. |
| In vitro | Method: 3T3-L1 cells overexpressing BMP8B were treated with TP0427736 hydrochloride (5 μM), and the effect on intracellular lipid levels was observed.
Result: TP0427736 hydrochloride effectively prevented the reduction of lipids in LV-Bmp8b cells. [1] |
| Synonyms | TP 0427736 hydrochloride |
| Molecular Weight | 334.85 |
| Formula | C14H11ClN4S2 |
| Cas No. | 2459963-17-6 |
| Smiles | Cl.N1=CSC=2C=C(C=CC12)C=3NC=NC3C4=NC(=CS4)C |
Storage & Solubility Information
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. | ||||||||||||||||||||
| Solubility Information | DMSO: 1 mg/mL (2.99 mM), Sonication is recommended. H2O: 2 mg/mL (5.97 mM), Sonication is recommended. | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO/H2O
H2O
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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