Shopping Cart
  • Remove All
  • TargetMol
    Your shopping cart is currently empty

GlyT

Glycine transporters (GlyTs) are plasmalemmal neurotransmitter transporters. They serve to terminate the signaling of glycine by mediating its reuptake from the synaptic cleft back into the presynaptic neurons. There are two glycine transporters: glycine transporter 1 (GlyT1) and glycine transporter 2 (GlyT2).

Bitopertin
T6788845614-11-1
Bitopertin (Paliflutine) (RG1678, RO-4917838) is a potent inhibitor of glycine transporter 1 (GlyT1), with Ki of 8.1 nM for human hGlyT1b and IC50 of 22-25 nM in Chinese hamster ovary cells.
  • $35
In Stock
Size
QTY
N-Arachidonylglycine
T23040179113-91-8
N-Arachidonylglycine (NA-Gly) is a heat-dependent circulating metabolite with anti-inflammatory, anticancer, antidiabetic and antioxidant activities.
  • $30
In Stock
Size
QTY
Org 25543 hydrochloride
T22126495076-64-7
Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor (IC50 = 16 nM for hGlyT2). Displays no activity at GlyT1 or 56 other common biological targets (≥ 100 μM), in a glycine uptake assay in CHO cells.
  • $76
In Stock
Size
QTY
Opiranserin hydrochloride
T98331440796-75-7
Opiranserin (VVZ-149) hydrochloride is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A), with IC50s of 0.86 and 1.3 μM, respectively. It shows antagonistic activity on rP2X3 (IC50=0.87 μM). It is development as an injectable agent for the treatment of postoperative pain.
  • $97
In Stock
Size
QTY
TargetMol | Inhibitor Sale
ALX-1393
T14198949164-09-4In house
ALX-1393 is a selective GlyT2 inhibitor that effectively reduces neuronal action potential activity in a concentration-dependent manner and inhibits the activity of spontaneous networks by inducing glycinergic tetanic currents in the abdominal horn of the spinal cord. Antiinjurious effects on thermal, mechanical and chemical stimuli in rat models of acute pain.
  • $1,380
In Stock
Size
QTY
GlyT1 Inhibitor 1
T114351820934-93-7
GlyT1 Inhibitor 1 is a selective and potent GlyT1 inhibitor, inhibiting rGlyT1, used in research on neurological disorders.
  • $1,400
6-8 weeks
Size
QTY
PF-03463275
T615641173239-39-8
PF-03463275 is an orally active and selective reversible inhibitor of competitive glycine transporter protein-1 (GlyT1) with a Ki of 11.6 nM.PF-03463275 has CNS permeability and may be used to ameliorate cognitive deficits associated with schizophrenia.
  • $51
In Stock
Size
QTY
Sarcosine
T6975107-97-1
Sarcosine (Methylglycine) is a competitive inhibitor of the type I glycine transporter (GlyT1) and an N-methyl-D-aspartate receptor (NMDAR) co-agonist.
  • $39
In Stock
Size
QTY
Amoxapine
T156814028-44-5
Amoxapine (CL-67772) exerts its antidepressant effect by inhibiting the re-uptake of norepinephrine and, to a lesser degree, of serotonin, at adrenergic nerve endings and blocks the response of dopamine receptors to dopamine. Amoxapine is a tricyclic antidepressant of the dibenzoxazepine class. This drug is used to treat symptoms of depression and may cause tardive dyskinesia. Amoxapine also binds to alpha-adrenergic, histaminergic, and cholinergic receptors which accounts for many of the side effects seen with this agent.
  • $31
In Stock
Size
QTY
LY2365109 hydrochloride
T119081779796-27-8
LY2365109 hydrochloride is a potent and selective GlyT1 inhibitor, with an IC50 of 15.8 nM for glycine uptake in cells over-expressing [hGlyT1a].
  • $34
In Stock
Size
QTY
TargetMol | Inhibitor Sale
ssr504734 hcl
T90597615571-23-8In house
SSR504734 is an orally active, selective, and reversible inhibitor of human, rat, and mouse GlyT1 (IC50 = 18, 15, and 38 nM, respectively). SSR504734 exhibits activity in schizophrenia, anxiety, and depression models [1].
  • $68
In Stock
Size
QTY
Stearoyl-L-carnitine chloride
T3773532350-57-5
Stearoyl-L-carnitine chloride (Acylcarnitine C18:0) is a long-chain acylcarnitine found in the cerebellum that inhibits GlyT2 and is an important component in the study of lipid metabolism.
  • $29
In Stock
Size
QTY
Iclepertin
T370891421936-85-7
Iclepertin (BI-425809) is an orally active and selective inhibitor of glycine transporter protein 1 (GlyT1).Iclepertin is used for the treatment of central nervous system disorders such as Alzheimer;s disease. Iclepertin is used for central nervous system disorders such as Alzheimer;s disease, schizophrenia and cognitive disorders.
  • $162
In Stock
Size
QTY
Tilapertin
T170961000690-85-6
Tilapertin is an oral glycine transporter type-1 inhibitor.
  • $1,520
6-8 weeks
Size
QTY
Opiranserin
T163991441000-45-8
Opiranserin is a development as an injectable agent for the treatment of postoperative pain. Opiranserin is a non-opioid and non-NSAID analgesic candidate and is a dual antagonist of glycine transporter type 2 (GlyT2) and serotonin receptor 2A (5HT2A) (IC50s: 0.86 and 1.3 μM, respectively). Opiranserin displays antagonistic activity on rP2X3 (IC50=0.87 μM).
  • $1,520
1-2 weeks
Size
QTY
NFPS
T16292405225-21-0
NFPS exerts neuroprotection via glyR alpha1 subunit in the rat model of transient focal cerebral ischaemia and reperfusion. NFPS is a selective and non-competitive glycine transporter-1 (GlyT1) inhibitor (IC50s: 2.8 nM and 9.8 nM for hGlyT1 and rGlyT1, respectively).
  • $957
35 days
Size
QTY
LY 2365109 hydrochloride
T22945868265-28-5
glycine transporter 1 (GlyT1) inhibitor
  • $1,520
6-8 weeks
Size
QTY
DCCCyb
T252921236046-15-3
DCCCyb is an orally bioavailable and selective GlyT1 Inhibitor. DCCCyb demonstrated excellent in vivo occupancy of GlyT1 transporters in rhesus monkeys as determined by the displacement of a PET tracer ligand.
  • Inquiry Price
3-6 months
Size
QTY
Org 24598
T37699372198-97-5
Potent and selective inhibitor of the glial glycine transporter GlyT1b (IC50 = 6.9 nM). Displays negligible activity at GlyT-2, adrenoreceptors, dopamine, 5HT receptors and noradrenaline, dopamine, 5HT and GABA transporters (pIC50 in vivo. Chue et al (2013) Glycine reuptake inhibition as a new therapeutic approach in schizophrenia: focus on the glycine transporter 1 (GlyT1). Curr.Pharm.Des. 19 1311 PMID:23194655 |Brown et al (2001) Discovery and SAR of org 24598-a selective glycine uptake inhibitor. Bioorg.Med.Chem.Lett. 11 2007 PMID:11454468 |Williams et al (2003) Development of a scintillation proximity assay for analysis of Na+/Cl- -dependent neurotransmitter transporter activity. Anal. Biochem. 321 31 PMID:12963052
  • $3,820
35 days
Size
QTY
pf-03463275 2hcl
T283641173177-11-1
PF-03463275 is an orally available, CNS-penetrant inhibitor of SLC6A9, a GlyT1 glycine transporter.
  • $1,520
6-8 weeks
Size
QTY
ssr504734
T28858742693-38-5
SSR504734 is a novel potent glycine transporter 1 (GlyT1) inhibitor.
  • $2,120
1-2 weeks
Size
QTY
Bitopertin (R enantiomer)
T10552845614-12-2
Bitopertin R enantiomer (RG1678 R enantiomer) is the R-enantiomer of Bitopertin, a noncompetitive glycine reuptake inhibitor that inhibits glycine uptake at human GlyT1 (IC50: 25 nM).
  • Inquiry Price
6-8 weeks
Size
QTY
org-25935
T28260949588-40-3
Org-25935, a GlyT-1 inhibitor, is used potentially for the treatment of schizophrenia and alcohol dependence.
  • $1,520
6-8 weeks
Size
QTY
VVZ-149
T35087
VVZ-149 is an antagonist of both serotonin receptor 2A (5HT2A) and glycine transporter type 2 (GlyT2), with potential anti-nociceptive activity.
  • Inquiry Price
Size
QTY