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Anti-HIV-1 gp120 Antibody (1K847)
🥰Excellent
Catalog No. TMAY-01786
Anti-HIV-1 gp120 Antibody (1K847) is a Mouse antibody targeting HIV-1 gp120. Anti-HIV-1 gp120 Antibody (1K847) can be used in WB,ELISA.
Anti-HIV-1 gp120 Antibody (1K847)
Anti-HIV-1 gp120 Antibody (1K847)
🥰Excellent
Catalog No. TMAY-01786
Anti-HIV-1 gp120 Antibody (1K847) is a Mouse antibody targeting HIV-1 gp120. Anti-HIV-1 gp120 Antibody (1K847) can be used in WB,ELISA.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-HIV-1 gp120 Antibody (1K847) is a Mouse antibody targeting HIV-1 gp120. Anti-HIV-1 gp120 Antibody (1K847) can be used in WB,ELISA. |
| Ig Type | Monoclonal Mouse IgG2b |
| Clone | 1K847 |
| Application | WB,ELISA |
| Recommended Dose | WB: his antibody can be used at 1:500-1:1000 with the appropriate secondary reagents to detect HIV-GP120-His in WB.; ELISA: 1:1000-1:2000 |
| Antibody Type | Monoclonal |
| Host Species | Mouse |
| Construction | This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant HIV-1 gp120 (TMPY-01373; Ala29-Glu502; AFM77980.1). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | The HIV-1 gp120 envelope protein, a glycoprotein that is part of the outer layer of the virus, is an essential component in the multi-tiered viral entry process. It presents itself as viral membrane spikes consisting of 3 molecules of gp120 linked together and anchored to the membrane by gp41 protein. Gp120 is essential for viral infection as it facilitates HIV entry into the host cell and this is its best-known and most researched role in HIV infection. However, it is becoming increasingly evident that gp120 might also be facilitating viral persistence and continuing HIV infection by influencing the T cell immune response to the virus. The surface protein gp120 attaches the virus to the host lymphoid cell by binding to the primary receptor CD4. Gp120 binding to its receptor CD4 and co-receptor, CXCR4 or CCR5 is required for fusion of viral and cellular membranes. Several mechanisms might be involved in this process of which gp120 binding to the CD4 receptor of T cells is the best known and most important interaction as it facilitates viral entry into the CD4+ cells and their depletion, a hallmark of the HIV infection. Gp120 is shed from the viral membrane and accumulates in lymphoid tissues in significant amounts. Despite the overall genetic heterogeneity of the gp120 glycoprotein, the conserved CD4 binding site provides an attractive antiviral target. Interaction between gp120 and ITGA4/ITGB7 would allow the virus to enter GALT early in the infection, infecting and killing most of GALT's resting CD4+ T-cells. This T-cell depletion is believed to be the major insult to the host immune system leading to AIDS. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant HIV-1 gp120 Protein (TMPY-01373) |
| Antigen Species | HIV |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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