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TYRA-300

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Catalog No. T88841Cas No. 2800223-30-5
Alias TYRA-300-B01, TYRA300

TYRA-300 is an oral and selective FGFR3 inhibitor with an IC50 value of 11 nM and 25-fold, 14-fold, and 36-fold selectivity for FGFR1, FGFR2, and FGFR4, respectively, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.

TYRA-300

TYRA-300

😃Good
Purity: 99.66%
Catalog No. T88841Alias TYRA-300-B01, TYRA300Cas No. 2800223-30-5
TYRA-300 is an oral and selective FGFR3 inhibitor with an IC50 value of 11 nM and 25-fold, 14-fold, and 36-fold selectivity for FGFR1, FGFR2, and FGFR4, respectively, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$392In StockIn Stock
5 mg$726In StockIn Stock
10 mg$987In StockIn Stock
25 mg$1,620-In Stock
50 mg$2,190-In Stock
100 mg$2,960-In Stock
1 mL x 10 mM (in DMSO)$893-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.66%
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COA HNMR HPLC

Product Introduction

Bioactivity
Description
TYRA-300 is an oral and selective FGFR3 inhibitor with an IC50 value of 11 nM and 25-fold, 14-fold, and 36-fold selectivity for FGFR1, FGFR2, and FGFR4, respectively, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.
Targets&IC50
FGFR2:157 nM, FGFR4:4045 nM, FGFR1:278 nM, FGFR3:11 nM
SynonymsTYRA-300-B01, TYRA300
Chemical Properties
Molecular Weight559.47
FormulaC25H24Cl2N6O3S
Cas No.2800223-30-5
SmilesS(C)(=O)(=O)N1CC2(CN(C2)C3=CC=C(C=N3)C=4C=5C(NN4)=CC=C(O[C@H](C)C=6C(Cl)=CN=CC6Cl)C5)C1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (142.99 mM), Sonication is recommended.
In Vivo Formulation
10% DMSO+40% PEG300+5% Tween-80+45% Saline: 5 mg/mL (8.94 mM), Sonication is recommeded.
Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7874 mL8.9370 mL17.8741 mL89.3703 mL
5 mM0.3575 mL1.7874 mL3.5748 mL17.8741 mL
10 mM0.1787 mL0.8937 mL1.7874 mL8.9370 mL
20 mM0.0894 mL0.4469 mL0.8937 mL4.4685 mL
50 mM0.0357 mL0.1787 mL0.3575 mL1.7874 mL
100 mM0.0179 mL0.0894 mL0.1787 mL0.8937 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
% DMSO
%
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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