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TYRA-300

🥰Excellent
Catalog No. T88841Cas No. 2800223-30-5
Alias TYRA-300-B01, TYRA300

TYRA-300 is an oral and selective FGFR3 inhibitor with an IC50 value of 11 nM and 25-fold, 14-fold, and 36-fold selectivity for FGFR1, FGFR2, and FGFR4, respectively, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.

TYRA-300

TYRA-300

🥰Excellent
Catalog No. T88841Alias TYRA-300-B01, TYRA300Cas No. 2800223-30-5
TYRA-300 is an oral and selective FGFR3 inhibitor with an IC50 value of 11 nM and 25-fold, 14-fold, and 36-fold selectivity for FGFR1, FGFR2, and FGFR4, respectively, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.
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Product Introduction

Bioactivity
Description
TYRA-300 is an oral and selective FGFR3 inhibitor with an IC50 value of 11 nM and 25-fold, 14-fold, and 36-fold selectivity for FGFR1, FGFR2, and FGFR4, respectively, in the Ba/F3 cell line for the treatment of metastatic uroepithelial carcinomas (mUCs) and chondrodysplasia.
Targets&IC50
FGFR4:4045 nM, FGFR3:11 nM, FGFR2:157 nM, FGFR1:278 nM
AliasTYRA-300-B01, TYRA300
Chemical Properties
Molecular Weight559.47
FormulaC25H24Cl2N6O3S
Cas No.2800223-30-5
SmilesS(C)(=O)(=O)N1CC2(CN(C2)C3=CC=C(C=N3)C=4C=5C(NN4)=CC=C(O[C@H](C)C=6C(Cl)=CN=CC6Cl)C5)C1
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (142.99 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.7874 mL8.9370 mL17.8741 mL89.3703 mL
5 mM0.3575 mL1.7874 mL3.5748 mL17.8741 mL
10 mM0.1787 mL0.8937 mL1.7874 mL8.9370 mL
20 mM0.0894 mL0.4469 mL0.8937 mL4.4685 mL
50 mM0.0357 mL0.1787 mL0.3575 mL1.7874 mL
100 mM0.0179 mL0.0894 mL0.1787 mL0.8937 mL

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