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LUF7996
Catalog No. T215953 Copy Product Info
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LUF7996 is a CCR2-targeting PROTAC degrader with a DC50 of 2.6 μM, designed to degrade CCR2 effectively. It binds simultaneously to CCR2 and the E3 ligase cereblon, demonstrating sustained and concentration-dependent degradation of CCR2. The compound induces CCR2 degradation via the lysosomal pathway and effectively inhibits monocyte migration in vitro.
LUF7996
Copy Product Info🥰Excellent
Catalog No. T215953
LUF7996 is a CCR2-targeting PROTAC degrader with a DC50 of 2.6 μM, designed to degrade CCR2 effectively. It binds simultaneously to CCR2 and the E3 ligase cereblon, demonstrating sustained and concentration-dependent degradation of CCR2. The compound induces CCR2 degradation via the lysosomal pathway and effectively inhibits monocyte migration in vitro.
LUF7996
Cas No. 3104736-80-0
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 10 mg | Inquiry | Inquiry | Inquiry | |
| 50 mg | Inquiry | Inquiry | Inquiry |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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With extensive experience in compound synthesis, we can provide rapid custom synthesis services for this product according to your research needs.
For research use only—not for human use. No sales to individuals. Use as intended only.
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | LUF7996 is a CCR2-targeting PROTAC degrader with a DC50 of 2.6 μM, designed to degrade CCR2 effectively. It binds simultaneously to CCR2 and the E3 ligase cereblon, demonstrating sustained and concentration-dependent degradation of CCR2. The compound induces CCR2 degradation via the lysosomal pathway and effectively inhibits monocyte migration in vitro. |
| Targets&IC50 | CCR2:2.6 μM (DC50) |
| In vitro | LUF7996 is a degrader targeting CCR2 PROTAC, capable of degrading CCR2 (with a DC50 of 2.6 μM). It can also simultaneously bind to CCR2 and the E3 ligase cereblon, exhibiting a sustained and concentration-dependent CCR2 degradation effect. LUF7996 induces CCR2 degradation through the lysosomal pathway and effectively inhibits monocyte migration in vitro. |
| Molecular Weight | 860.68 |
| Formula | C39H34Cl2F3N5O8S |
| Cas No. | 3104736-80-0 |
| Smiles | O=C(NCCCCCCNC1=CC=CC=2C(=O)N(C(=O)C12)C3C(=O)NC(=O)CC3)C4=CC=C(OC5=CC=C(Cl)C=C5NS(=O)(=O)C6=CC=C(Cl)C(=C6)C(F)(F)F)C=C4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year Shipping with blue ice/Shipping at ambient temperature. |
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:
For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, and a total of 10 animals are to be administered, using a formulation of 
10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH2O , the resulting working solution concentration would be 2 mg/mL.Stock Solution Preparation:
Dissolve 2 mg of the compound in 100 μL DMSO to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.
Preparation of the In Vivo Formulation:
1) Add 100 μL of the DMSO stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.
2) Add 50 μL Tween 80 and mix well until fully clarified.
3) Add 450 μL Saline,PBS or ddH2O and mix thoroughly until a homogeneous solution is obtained.
This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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