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TrkB Protein, Human, Recombinant (His)

Catalog No. TMPY-00751
Synonyms: trk-B, GP145-TrkB/GP95-TrkB, neurotrophic tyrosine kinase, receptor, type 2, TRKB, GP145-TrkB, Tkrb

TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2.

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TrkB Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
100 μg In stock $ 228.00
200 μg 5 days $ 418.00
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Biological Description
Technical Params
Product Properties
References and Literature
Biological Information Measured by its ability to bind Mouse/Human BDNF Protein (Native) in a functional ELISA.
Description TrkB Protein, Human, Recombinant (His) is expressed in HEK293 mammalian cells with His tag. The predicted molecular weight is 45.7 kDa and the accession number is Q16620-2.
Species Human
Expression System HEK293 Cells
Tag C-His
Accession Number Q16620-2
Synonyms trk-B, GP145-TrkB/GP95-TrkB, neurotrophic tyrosine kinase, receptor, type 2, TRKB, GP145-TrkB, Tkrb
Construction extracellular domain (Met 1-His 430) of Human TrkB (NP_001007098.1) precursor
Protein Purity ≥ 97 % as determined by SDS-PAGE. ≥ 90 % as determined by SEC-HPLC.

Molecular Weight 45.7 kDa (predicted)
Endotoxin < 1.0 EU/μg of the protein as determined by the LAL method.
Formulation Lyophilized from a solution filtered through a 0.22 μm filter, containing PBS, pH 7.4. Typically, a mixture containing 5% to 8% trehalose, mannitol, and 0.01% Tween 80 is incorporated as a protective agent before lyophilization.
Reconstitution A Certificate of Analysis (CoA) containing reconstitution instructions is included with the products. Please refer to the CoA for detailed information.
Stability & Storage

It is recommended to store recombinant proteins at -20°C to -80°C for future use. Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at-80℃. For reconstituted protein solutions, the solution can be stored at -20°c to -80'c for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.

Shipping

In general, Lyophilized powders are shipping with blue ice.

Research Background TrkB receptor also known as TrkB tyrosine kinase or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 (NTRK2) is a single transmembrane catalytic receptor with intracellular tyrosine kinase activity. TrkB/NTRK2 is a member of the neurotrophic tyrosine receptor kinase (NTRK) family. TrkB tyrosine kinase (TrkB) or NTRK2 is coupled to the Ras, Cdc42/Rac/RhoG, MAPK, PI3-K, and PLCgamma signaling pathways. There are four members of the Trk family; TrkA, TrkB, and TrkC and a related p75NTR receptor. Each family member binds different neurotrophins with varying affinities. TrkB/NTRK has the highest affinity for brain-derived neurotrophic factor (BDNF) and is involved in neuronal plasticity, long-term potentiation, and apoptosis of CNS neurons. Other neurotrophins includenerve growth factor(NGF), neurotrophin-3 and neurotrophin-4. TrkB/NTRK is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signaling through this kinase leads to cell differentiation. Mutations in TrkB/NTRK have been associated with obesity and mood disorders.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

References and Literature

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Keywords

TrkB Protein, Human, Recombinant (His) trk-B GP145-TrkB/GP95-TrkB neurotrophic tyrosine kinase, receptor, type 2 TRKB GP145-TrkB Tkrb recombinant recombinant-proteins proteins protein

 

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