CD19 Protein, Human, Recombinant (CHO, hFc)

Catalog No. TMPY-05427U

CD19 Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is P15391.

CD19 Protein, Human, Recombinant (CHO, hFc)

Catalog No. TMPY-05427U

CD19 Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is P15391.

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Product Information

Biological Activity	Immobilized Human FMC63 at 2 μg/ml (100 μl/well) can bind Human CD19-Fc. The ED50 of Recombinant Human CD19-Fc is 55.28 ng/ml. Loaded Anti-Human CD19 mAb-Fc on AMC Biosensor, can bind Human CD19-FC with an affinity constant of 2.72 nM as determined in BLI assay.
Description	CD19 Protein, Human, Recombinant (CHO, hFc) is expressed in CHO Cells. The accession number is P15391.
Species	Human
Expression System	CHO Cells
Tag	C-Fc
Accession Number	P15391
Synonyms	CVID3,CD19 molecule,B4
Construction	Pro20-Lys291
Protein Purity	> 95% as determined by SDS-PAGE
Molecular Weight	57.3 kDa (Predicted); 80-95 kDa (Reducing conditions)
Endotoxin	< 1.0 EU/μg of the protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution of 20 mM PB, 150 mM NaCl, pH 7.4.
Stability & Storage	Lyophilized powders can be stably stored for over 12 months, while liquid products can be stored for 6-12 months at -80°C. For reconstituted protein solutions, the solution can be stored at -20°C to -80°C for at least 3 months. Please avoid multiple freeze-thaw cycles and store products in aliquots.
Shipping	In general, Lyophilized powders are shipping with blue ice. Solutions are shipping with dry ice.
Research Background	CD19 is a single-pass type I membrane protein containing 2 Ig-like C2-type (immunoglobulin-like) domains. CD19 is expressed on follicular dendritic cells and B cells. In fact, it is present on B cells from earliest recognizable B-lineage cells during development to B-cell blasts but is lost on maturation to plasma cells. CD19 primarily acts as a B cell co-receptor in conjunction with CD21 and CD81. Upon activation, the cytoplasmic tail of CD19 becomes phosphorylated, which leads to binding by Src-family kinases and recruitment of PI-3 kinase. CD19 Assembles with the antigen receptor of B lymphocytes in order to decrease the threshold for antigen receptor-dependent stimulation.