Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
10 μg | In stock | $ 118.00 | |
50 μg | 5 days | $ 350.00 | |
500 μg | 5 days | $ 2,360.00 | |
1 mg | 5 days | $ 3,790.00 |
Biological Information |
Measured by its ability to inhibit the IL-4-dependent proliferation of TF-1 cells. The ED50 for this effect is 30-180pg/ml. (QC verified)
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Description | Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). |
Species | Human |
Expression System | Human Cells |
Tag | None |
Accession Number | P61812 |
Synonyms | Glioblastoma-derived T-cell suppressor factor, TGF-β-2, Transforming growth factor β-2, Transforming growth factor beta-2, Cetermin, BSC-1 cell growth inhibitor, TGFB2, TGF-beta-2, Polyergin, G-TSF, TGF-β2 |
Amino Acid | Ala303-Ser414 |
Construction | Recombinant Human Transforming Growth Factor Beta 2 is produced by our Mammalian expression system and the target gene encoding Ala303-Ser414 is expressed. |
Protein Purity |
Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
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Molecular Weight | 12 KDa, reducing conditions |
Endotoxin | Less than 0.001 ng/µg (0.01 EU/µg) as determined by LAL test. |
Formulation | Lyophilized from a 0.2 μm filtered solution of 4mM HCl. |
Reconstitution | Always centrifuge tubes before opening.Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100μg/ml. Dissolve the lyophilized protein in distilled water. Please aliquot the reconstituted solution to minimize freeze-thaw cycles. |
Stability & Storage |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. Reconstituted protein solution can be stored at 2-8°C for 2-7 days. Aliquots of reconstituted samples are stable at ≤ -20°C for 3 months. |
Shipping |
The product is shipped at ambient temperature. Upon receipt, store it immediately at the temperature listed below. |
Research Background | Transforming growth factor beta-2 (TGF-β2) is a secreted protein which belongs to the TGF-beta family. It is known as a cytokine that performs many cellular functions and has a vital role during embryonic development. The precursor is cleaved into mature TGF-beta-2 and LAP, which remains non-covalently linked to mature TGF-beta-2 rendering it inactive. It is an extracellular glycosylated protein. It is known to suppress the effects of interleukin dependent T-cell tumors. Defects in TGFB2 may be a cause of non-syndromic aortic disease (NSAD). |
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Please read the User Guide of Recombinant Proteins for more specific information.
TGF beta 2 Protein, Human, Recombinant TGFB 2 TGF-b-2 Glioblastoma-derived T-cell suppressor factor TGF-β-2 Transforming growth factor β-2 Transforming growth factor beta-2 Cetermin TGFB-2 BSC-1 cell growth inhibitor Transforming growth factor b-2 TGFB2 TGF-beta-2 Polyergin G-TSF TGF-β2 recombinant recombinant-proteins proteins protein