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Avibactam tomilopil

🥰Excellent
Catalog No. T39758Cas No. 2245880-46-8
Alias AV-006, AV006, ARX-1796, ARX1796

Avibactam tomilopil (AV-006) is an orally bioavailable prodrug of Avibactam and functions as a β-lactamase inhibitor. Avibactam tomilopil effectively releases Avibactam, which inhibits class A and C β-lactamases, including extended-spectrum β-lactamases (ESBLs), AmpC enzymes, and Klebsiella pneumoniae carbapenemase (KPC), thereby broadening antibacterial coverage.

Avibactam tomilopil

Avibactam tomilopil

🥰Excellent
Purity: 97.639%
Catalog No. T39758Alias AV-006, AV006, ARX-1796, ARX1796Cas No. 2245880-46-8
Avibactam tomilopil (AV-006) is an orally bioavailable prodrug of Avibactam and functions as a β-lactamase inhibitor. Avibactam tomilopil effectively releases Avibactam, which inhibits class A and C β-lactamases, including extended-spectrum β-lactamases (ESBLs), AmpC enzymes, and Klebsiella pneumoniae carbapenemase (KPC), thereby broadening antibacterial coverage.
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Purity:97.639%
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Product Introduction

Bioactivity
Description
Avibactam tomilopil (AV-006) is an orally bioavailable prodrug of Avibactam and functions as a β-lactamase inhibitor. Avibactam tomilopil effectively releases Avibactam, which inhibits class A and C β-lactamases, including extended-spectrum β-lactamases (ESBLs), AmpC enzymes, and Klebsiella pneumoniae carbapenemase (KPC), thereby broadening antibacterial coverage.
In vivo
Avibactam tomilopil is an orally administered prodrug that is converted into the active ingredient Avibactam in vivo. When used in combination with Ceftibuten, Avibactam protects this β-lactam antibiotic from degradation by inhibiting enzymes produced by Gram-negative bacteria, thereby exerting synergistic antibacterial effects. [1]
SynonymsAV-006, AV006, ARX-1796, ARX1796
Chemical Properties
Molecular Weight393.41
FormulaC14H23N3O8S
Cas No.2245880-46-8
SmilesC(N)(=O)[C@H]1[N@@]2C(=O)N(OS(OCC(C(OCC)=O)(C)C)(=O)=O)[C@@](C2)(CC1)[H]
ColorYellow
AppearanceSolid
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (203.35 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.5419 mL12.7094 mL25.4188 mL127.0939 mL
5 mM0.5084 mL2.5419 mL5.0838 mL25.4188 mL
10 mM0.2542 mL1.2709 mL2.5419 mL12.7094 mL
20 mM0.1271 mL0.6355 mL1.2709 mL6.3547 mL
50 mM0.0508 mL0.2542 mL0.5084 mL2.5419 mL
100 mM0.0254 mL0.1271 mL0.2542 mL1.2709 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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g
μL
2 Enter the in vivo formulation:
% DMSO
%
% Tween 80
% Saline/PBS/ddH2O

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

AV 006ARX 1796
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