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Avibactam tomilopil

Name: Avibactam tomilopil
Brand: TargetMol
SKU: T39758
Price: 810 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T39758Cas No. 2245880-46-8

Alias AV-006, AV006, ARX-1796, ARX1796

Avibactam tomilopil (AV-006) is an orally bioavailable prodrug of Avibactam and functions as a β-lactamase inhibitor. Avibactam tomilopil effectively releases Avibactam, which inhibits class A and C β-lactamases, including extended-spectrum β-lactamases (ESBLs), AmpC enzymes, and Klebsiella pneumoniae carbapenemase (KPC), thereby broadening antibacterial coverage.

Avibactam tomilopil

🥰Excellent

Purity: 97.639%

Catalog No. T39758Alias AV-006, AV006, ARX-1796, ARX1796Cas No. 2245880-46-8

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$108	-	In Stock
2 mg	$158	-	In Stock
5 mg	$265	-	In Stock
10 mg	$430	-	In Stock
25 mg	$810	-	In Stock
50 mg	Preferential	-	In Stock
1 mL x 10 mM (in DMSO)	$292	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:97.639%

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COA LCMS HNMR

Product Introduction

Bioactivity

Description	Avibactam tomilopil (AV-006) is an orally bioavailable prodrug of Avibactam and functions as a β-lactamase inhibitor. Avibactam tomilopil effectively releases Avibactam, which inhibits class A and C β-lactamases, including extended-spectrum β-lactamases (ESBLs), AmpC enzymes, and Klebsiella pneumoniae carbapenemase (KPC), thereby broadening antibacterial coverage.
In vivo	Avibactam tomilopil is an orally administered prodrug that is converted into the active ingredient Avibactam in vivo. When used in combination with Ceftibuten, Avibactam protects this β-lactam antibiotic from degradation by inhibiting enzymes produced by Gram-negative bacteria, thereby exerting synergistic antibacterial effects. [1]
Synonyms	AV-006, AV006, ARX-1796, ARX1796

Chemical Properties

Molecular Weight	393.41
Formula	C₁₄H₂₃N₃O₈S
Cas No.	2245880-46-8
Smiles	C(N)(=O)[C@H]1[N@@]2C(=O)N(OS(OCC(C(OCC)=O)(C)C)(=O)=O)[C@@](C2)(CC1)[H]
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 80 mg/mL (203.35 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween-80+45% Saline: 3.3 mg/mL (8.39 mM), Sonication is recommeded.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5419 mL	12.7094 mL	25.4188 mL	127.0939 mL
5 mM	0.5084 mL	2.5419 mL	5.0838 mL	25.4188 mL
10 mM	0.2542 mL	1.2709 mL	2.5419 mL	12.7094 mL
20 mM	0.1271 mL	0.6355 mL	1.2709 mL	6.3547 mL
50 mM	0.0508 mL	0.2542 mL	0.5084 mL	2.5419 mL
100 mM	0.0254 mL	0.1271 mL	0.2542 mL	1.2709 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc