Shopping Cart

Your shopping cart is currently empty

ATM-3507 trihydrochloride (1861449-70-8 free base)

Name: ATM-3507 trihydrochloride (1861449-70-8 free base)
Brand: TargetMol
SKU: T10395
Rating: 4.5 (1 reviews)

😃Good

Catalog No. T10395

Alias ATM-3507 trihydrochloride

ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84 μM in human melanoma cell lines).

ATM-3507 trihydrochloride (1861449-70-8 free base)

😃Good

Catalog No. T10395Alias ATM-3507 trihydrochloride

ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84 μM in human melanoma cell lines).

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$2,120	10-14 weeks	10-14 weeks
50 mg	$2,780	10-14 weeks	10-14 weeks
100 mg	$3,700	10-14 weeks	10-14 weeks

Add to Cart

Add to Quotation

In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

Questions

Resource Download

Product Introduction

Bioactivity

Description	ATM-3507 trihydrochloride is a potent tropomyosin inhibitor (IC50s: 3.83-6.84 μM in human melanoma cell lines).
Targets&IC50	Tropomyosin (human melanoma cells):3.83-6.84 μM
In vivo	The maximal tolerance dose (MTD) for TR100 and ATM-3507 is 60 and 150 mg/kg, respectively. The median survival of mice increased from 18 days for mice treated with ATM-3507 to more than 49 days for mice treated with the combination. It is also found that twice-weekly intravenous administration of ATM-3507 also shows combination efficacy. The impact of each treatment or the combination of body weight is minimal. Drug levels are measured following the intravenous administration of ATM-3507 at 30 mg/kg in Balb/c mice (n=3 per time point). The mean half-life of ATM-3507 is 5.01 hrs for the terminal elimination phase. The mean AUC0-t in the plasma is 14,548 ng/h/mL. The Cmax of ATM-3507 is 5,758 ng/mL and the t1/2 is 5.01 h. The observed plasma clearance and volume of distribution at steady state of ATM-3507 is 33.8 mL/min/kg and 7.23 L/kg, respectively.
Synonyms	ATM-3507 trihydrochloride

Chemical Properties

Molecular Weight	721.17
Formula	C₃₇H₄₉Cl₃FN₅O₂
Smiles	O=C(C1=CC=CC(OC2=CC3=C(N(CCCN4CCN(C)CC4)C(C)=C3C)C=C2)=C1)N5CCN(CCC6=CC=C(F)C=C6)CC5.Cl.Cl.Cl
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 250 mg/mL (346.66 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.3866 mL	6.9332 mL	13.8664 mL	69.3318 mL
5 mM	0.2773 mL	1.3866 mL	2.7733 mL	13.8664 mL
10 mM	0.1387 mL	0.6933 mL	1.3866 mL	6.9332 mL
20 mM	0.0693 mL	0.3467 mL	0.6933 mL	3.4666 mL
50 mM	0.0277 mL	0.1387 mL	0.2773 mL	1.3866 mL
100 mM	0.0139 mL	0.0693 mL	0.1387 mL	0.6933 mL

Calculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculator
Molecular Weight Calculator

In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

Keywords

tropomyosin, in human melanoma celllinesATM3507 trihydrochloride (1861449708 free base)ATM-3507 TrihydrochlorideATM3507 TrihydrochlorideATM-3507ATM3507ATM 3507 trihydrochloride (1861449 70 8 free base)ATM 3507 TrihydrochlorideATM 35071861449-70-8 free base1861449-70-8

Related Tags: buy ATM-3507 trihydrochloride (1861449-70-8 free base) | purchase ATM-3507 trihydrochloride (1861449-70-8 free base) | ATM-3507 trihydrochloride (1861449-70-8 free base) cost | order ATM-3507 trihydrochloride (1861449-70-8 free base) | ATM-3507 trihydrochloride (1861449-70-8 free base) chemical structure | ATM-3507 trihydrochloride (1861449-70-8 free base) in vivo | ATM-3507 trihydrochloride (1861449-70-8 free base) formula | ATM-3507 trihydrochloride (1861449-70-8 free base) molecular weight