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Anti-Phospho-SHIP1 (Tyr1020) Polyclonal Antibody
🥰Excellent
Catalog No. TMAB-11281
Antibody Type: Rabbit Polyclonal
Application: WB
Reactivity: Mouse (predicted:Human,Rat,Dog,Pig,Cow)
Anti-Phospho-SHIP1 (Tyr1020) Polyclonal Antibody
Anti-Phospho-SHIP1 (Tyr1020) Polyclonal Antibody
🥰Excellent
Catalog No. TMAB-11281
Antibody Type: Rabbit Polyclonal
Application: WB
Reactivity: Mouse (predicted:Human,Rat,Dog,Pig,Cow)
Application: WB
Reactivity: Mouse (predicted:Human,Rat,Dog,Pig,Cow)
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Product Introduction
Bioactivity
Antigen Details
Chemical Properties
| Description | Anti-Phospho-SHIP1 (Tyr1020) Polyclonal Antibody is a Rabbit antibody targeting Phospho-SHIP1 (Tyr1020). Anti-Phospho-SHIP1 (Tyr1020) Polyclonal Antibody can be used in WB. |
| Ig Type | IgG |
| Reactivity | Mouse (predicted:Human,Rat,Dog,Pig,Cow) |
| Application | |
| Recommended Dose | WB: 1:500-2000 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cytoplasm (By similarity). Membrane; Peripheral membrane protein (By similarity). Note=Translocates to the plasma membrane when activated, translocation is probably due to different mechanisms depending on the stimulus and cell type. Partly translocated via its SH2 domain which mediates interaction with tyrosine phosphorylated receptors such as the FC-gamma-RIIB receptor (FCGR2B) or CD16/FCGR3. Tyrosine phosphorylation may also participate in membrane localization (By similarity). |
| Tissue Specificity | Specifically expressed in immune and hematopoietic cells. Expressed in bone marrow and blood cells. |
| Construction | Hybridoma Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | SHIP1 is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and contains an N-terminal SH2 domain, an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to hematopoietic cells where its movement from the cytosol to the plasma membrane is mediated by tyrosine phosphorylation in response to multiple cytokine and B and T cell receptor activation. At the plasma membrane, the protein hydrolyzes the 5' phosphate from phosphatidylinositol (3,4,5)-trisphosphate and inositol-1,3,4,5-tetrakisphosphate, thereby affecting multiple signaling pathways. Overall the protein functions as a negative regulator of myeliod cell proliferation and survival. |
| Immunogen | KLH conjugated Synthesised phosphopeptide: rat SHIP1 around the phosphorylation site of Tyr1020 |
| Antigen Species | Rat |
| Gene Name | INPP5D |
| Gene ID | |
| Protein Name | Phosphatidylinositol 3, 4, 5-trisphosphate 5-phosphatase 1 |
| Function | Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol-3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Acts as a negative regulator of B-cell antigen receptor signaling. Mediates signaling from the FC-gamma-RIIB receptor (FCGR2B), playing a central role in terminating signal transduction from activating immune/hematopoietic cell receptor systems. Acts as a negative regulator of myeloid cell proliferation/survival and chemotaxis, mast cell degranulation, immune cells homeostasis, integrin alpha-IIb/beta-3 signaling in platelets and JNK signaling in B-cells. Regulates proliferation of osteoclast precursors, macrophage programming, phagocytosis and activation and is required for endotoxin tolerance. Involved in the control of cell-cell junctions, CD32a signaling in neutrophils and modulation of EGF-induced phospholipase C activity. Key regulator of neutrophil migration, by governing the formation of the leading edge and polarization required for chemotaxis. Modulates FCGR3/CD16-mediated cytotoxicity in NK cells. Mediates the activin/TGF-beta-induced apoptosis through its Smad-dependent expression. May also hydrolyze PtdIns(1,3,4,5)P4, and could thus affect the levels of the higher inositol polyphosphates like InsP6 (By similarity). |
| Molecular Weight | Theoretical: 134 kDa. |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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