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Anti-Bad Antibody (4Z819)
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Catalog No. TMAC-00365
Alias Proapoptotic BH3 Only Protein, Bcl-XL/Bcl-2-associated death promoter, Bcl-2-like protein 8, Bcl2-L-8, BCL2L8, Bcl-2-binding component 6, Bcl2 Like 8 Protein, Bcl2 binding protein, BCL2 binding component 6, Bcl2 Associated Death Promoter, BCL2 associated agonist of cell death, BCL2 antagonist of cell death protein, Bcl2 antagonist of cell death, Bcl XL/Bcl 2 Associated Death Promoter, BCL X Binding Protein, BCL X / BCL 2 Binding Protein, Bcl 2 Binding Component 6, Bcl 2 Antagonist of Cell Death, BBC6, BBC2, BBC 2, BAD_HUMAN, BAD, AI325008
Anti-Bad Antibody (4Z819) is a Rabbit antibody targeting Bad. Anti-Bad Antibody (4Z819) can be used in FCM,ICC/IF,IHC,IP,WB.
Anti-Bad Antibody (4Z819)
Anti-Bad Antibody (4Z819)
😃Good
Catalog No. TMAC-00365Alias Proapoptotic BH3 Only Protein, Bcl-XL/Bcl-2-associated death promoter, Bcl-2-like protein 8, Bcl2-L-8, BCL2L8, Bcl-2-binding component 6, Bcl2 Like 8 Protein, Bcl2 binding protein, BCL2 binding component 6, Bcl2 Associated Death Promoter, BCL2 associated agonist of cell death, BCL2 antagonist of cell death protein, Bcl2 antagonist of cell death, Bcl XL/Bcl 2 Associated Death Promoter, BCL X Binding Protein, BCL X / BCL 2 Binding Protein, Bcl 2 Binding Component 6, Bcl 2 Antagonist of Cell Death, BBC6, BBC2, BBC 2, BAD_HUMAN, BAD, AI325008
Anti-Bad Antibody (4Z819) is a Rabbit antibody targeting Bad. Anti-Bad Antibody (4Z819) can be used in FCM,ICC/IF,IHC,IP,WB.
| Pack Size | Price | USA Warehouse | Global Warehouse | Quantity |
|---|---|---|---|---|
| 50 μL | $296 | 7-10 days | 7-10 days | |
| 100 μL | $498 | 7-10 days | 7-10 days |
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-Bad Antibody (4Z819) is a Rabbit antibody targeting Bad. Anti-Bad Antibody (4Z819) can be used in FCM,ICC/IF,IHC,IP,WB. |
| Synonyms | Proapoptotic BH3 Only Protein, Bcl-XL/Bcl-2-associated death promoter, Bcl-2-like protein 8, Bcl2-L-8, BCL2L8, Bcl-2-binding component 6, Bcl2 Like 8 Protein, Bcl2 binding protein, BCL2 binding component 6, Bcl2 Associated Death Promoter, BCL2 associated agonist of cell death, BCL2 antagonist of cell death protein, Bcl2 antagonist of cell death, Bcl XL/Bcl 2 Associated Death Promoter, BCL X Binding Protein, BCL X / BCL 2 Binding Protein, Bcl 2 Binding Component 6, Bcl 2 Antagonist of Cell Death, BBC6, BBC2, BBC 2, BAD_HUMAN, BAD, AI325008 |
| Ig Type | IgG |
| Clone | 4Z819 |
| Reactivity | Human,Mouse,Rat |
| Verified Activity | 1. Western blot analysis of Bad on MCF-7 cell lysates using anti-Bad antibody at 1/500 dilution. 2. ICC staining Bad in Hela cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 3. ICC staining Bad in MCF-7 cells (green). The nuclear counter stain is DAPI (blue). Cells were fixed in paraformaldehyde, permeabilised with 0.25% Triton X100/PBS. 4. Flow cytometric analysis of Hela cells with Bad antibody at 1/50 dilution (blue) compared with an unlabelled control (cells without incubation with primary antibody; red). Alexa Fluor 488-conjugated goat anti rabbit IgG was used as the secondary antibody.     |
| Application | |
| Recommended Dose | WB: 1:500-1000; IHC: 1:50-200; ICC/IF: 1:50-200; FCM: 1:10-100 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Recombinant Antibody |
| Purification | ProA affinity purified |
| Appearance | Liquid |
| Formulation | 1*TBS (pH7.4), 1%BSA, 40%Glycerol. Preservative: 0.05% Sodium Azide. |
| Research Background | The Bcl-2 family of proteins is characterized by its ability to modulate cell death (apoptosis) under a broad range of physiologic conditions. Bcl-2 and several related proteins function to inhibit apoptosis while other members of the Bcl-2 family, such as Bax and Bak, enhance cell death under various conditions. For instance, Bcl-xL represses cell death, while its shorter form, Bcl-xS, promotes apoptosis. A protein designated Bad exhibits homology to Bcl-2 limited to the BH1 and BH2 domains. Bad functions to dimerize with Bcl-xL and with Bcl-2, but not with Bax, Bcl-xS, Mcl-1, A1 or itself. In mammalian cells, Bad binds with greater affinity to Bcl-xL than to Bcl-2 and reverses the death repressor activity of Bcl-xL but not Bcl-2. Dimerization of Bad with Bcl-xL results in displacement of Bax from Bcl-xL:Bax complexes thereby causing restoration of Bax-mediated apoptosis. |
| Conjucates | Unconjugated |
| Immunogen | Recombinant Protein |
| Uniprot ID |
| Molecular Weight | Theoretical: 23 kDa. |
Stability & Storage
| Stability & Storage | Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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