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Anti-Claudin-18 Antibody (5S243)

😃Good
Catalog No. TMAY-01430
Alias SFTPJ, SFTA5, claudin 18

Anti-Claudin-18 Antibody (5S243) is a Rabbit antibody targeting Claudin-18. Anti-Claudin-18 Antibody (5S243) can be used in IHC-P.

Anti-Claudin-18 Antibody (5S243)

Anti-Claudin-18 Antibody (5S243)

😃Good
Catalog No. TMAY-01430Alias SFTPJ, SFTA5, claudin 18
Anti-Claudin-18 Antibody (5S243) is a Rabbit antibody targeting Claudin-18. Anti-Claudin-18 Antibody (5S243) can be used in IHC-P.
Pack SizePriceAvailabilityQuantity
20 μL$139 7-10 days
100 μL$375 7-10 days
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Product Introduction

Bioactivity
Description
Anti-Claudin-18 Antibody (5S243) is a Rabbit antibody targeting Claudin-18. Anti-Claudin-18 Antibody (5S243) can be used in IHC-P.
AliasSFTPJ, SFTA5, claudin 18
Ig Type
Monoclonal Rabbit IgG
Clone
5S243
Reactivity
Human, Has cross-reactivity in IHC with human Claudin 18.1 and Claudin 18.2
Verified Activity
1. Immunochemical staining of human Claudin 18 in human stomach with rabbit monoclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections.

2. Immunochemical staining of human Claudin 18 in human gastric cancer with rabbit monoclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections.

3. Immunochemical staining of human Claudin 18 in human lung with rabbit monoclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections.
Application
IHC-P
Recommended Dose
IHC-P: 1:5000-1:20000
Antibody Type
Monoclonal
Host SpeciesRabbit
ConstructionProduced in rabbits immunized with a synthetic peptide corresponding to the human Claudin 18, and purified by antigen affinity chromatography.
PurificationProtein A
AppearanceLiquid
Formulation0.2 μm filtered solution in PBS
Research BackgroundClaudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, and signaling. CLDN18 deficiency has been associated with atrophic gastritis, spasmolytic polypeptide-expressing metaplasia (SPEM), and asthma. Lung-specific CLDN18.1 modulates alveolar epithelial type II (AT2) cell proliferation and organ size. Restoration of CLDN18.1 expression in human lung cancer cells has been shown to suppress proliferation, inhibiting the IGF-1R/AKT axes. Not expressed in other healthy tissues, gastric mucosa-specific isoform CLDN18.2 expression manifests in primary gastric cancers. CLDN18.2 at the surface of epithelial tumor cells is a target in antibody and CAR-therapies currently in development.
Related Conjugates and Formulations
Conjucates
Unconjugated
Antigen Details
Immunogen
A synthetic peptide corresponding to the human Claudin 18
Antigen Species
Human
Chemical Properties
Stability & Storage
Stability & StorageStore at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
TransportShipping with blue ice.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc

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