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Anti-Claudin-18 Antibody (5S243)
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Catalog No. TMAY-01430
Alias SFTPJ, SFTA5, CLDN18, CLDN 18, claudin 18
Anti-Claudin-18 Antibody (5S243) is a Rabbit antibody targeting Claudin-18. Anti-Claudin-18 Antibody (5S243) can be used in IHC-P.
Anti-Claudin-18 Antibody (5S243)
Anti-Claudin-18 Antibody (5S243)
😃Good
Catalog No. TMAY-01430Alias SFTPJ, SFTA5, CLDN18, CLDN 18, claudin 18
Anti-Claudin-18 Antibody (5S243) is a Rabbit antibody targeting Claudin-18. Anti-Claudin-18 Antibody (5S243) can be used in IHC-P.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 20 μL | $139 | 7-10 days | |
| 100 μL | $375 | 7-10 days |
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Antibody Type: Rabbit Monoclonal Application: IHC-P Reactivity: Human |
| Alias | SFTPJ, SFTA5, CLDN18, CLDN 18, claudin 18 |
| Ig Type | Rabbit IgG |
| Clone | 5S243 |
| Reactivity | Human, Has cross-reactivity in IHC with human Claudin 18.1 and Claudin 18.2 |
| Verified Activity | 1. Immunochemical staining of human Claudin 18 in human stomach with rabbit monoclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections. 2. Immunochemical staining of human Claudin 18 in human gastric cancer with rabbit monoclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections. 3. Immunochemical staining of human Claudin 18 in human lung with rabbit monoclonal antibody at 1:10000 dilution, formalin-fixed paraffin embedded sections. |
| Application | IHC-P |
| Recommended Dose | IHC-P: 1:5000-1:20000 |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | Produced in rabbits immunized with a synthetic peptide corresponding to the human Claudin 18, and purified by antigen affinity chromatography. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | 0.2 μm filtered solution in PBS |
| Research Background | Claudins family member Claudin18 (CLDN18) is a four-pass transmembrane protein with two extracellular loops and cytoplasmic N- and C-tails found in tight junctions. CLDN18 modulates paracellular permeability, polarity, and signaling. CLDN18 deficiency has been associated with atrophic gastritis, spasmolytic polypeptide-expressing metaplasia (SPEM), and asthma. Lung-specific CLDN18.1 modulates alveolar epithelial type II (AT2) cell proliferation and organ size. Restoration of CLDN18.1 expression in human lung cancer cells has been shown to suppress proliferation, inhibiting the IGF-1R/AKT axes. Not expressed in other healthy tissues, gastric mucosa-specific isoform CLDN18.2 expression manifests in primary gastric cancers. CLDN18.2 at the surface of epithelial tumor cells is a target in antibody and CAR-therapies currently in development. |
| Conjucates | Unconjugated |
| Immunogen | A synthetic peptide: human Claudin 18 |
| Antigen Species | Human |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free. |
| Transport | Shipping with blue ice. |
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