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Seocalcitol

Name: Seocalcitol
Brand: TargetMol
SKU: T19559
Rating: 4.5 (1 reviews)

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Catalog No. T19559Cas No. 134404-52-7

Alias EB 1089

Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM).

Seocalcitol

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Catalog No. T19559Alias EB 1089Cas No. 134404-52-7

Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM).

Pack Size	Price	USA Warehouse	Global Warehouse
500 μg	$352	35 days	35 days
1 mg	$667	35 days	35 days
5 mg	$2,790	35 days	35 days

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Seocalcitol is an analog of vitamin D, binds vitamin D receptor protein from human osteosarcoma MG-63 cells(Kd : 0.27 nM).
Targets&IC50	Vitamin D receptor:(kd)0.27 nM
In vitro	Seocalcitol is a stimulators of osteoclast recruitment in murine bone marrow cultures(EC50 at 0.1 nM). Seocalcitol stimulates bone resorption(EC50 of 0.03 nM)[1]. Seocalcitol elicites a dose-dependent induction of 24-hydroxylase mRNA in the kidney (EC50=0.4±0.13). In the kidney, Kd values for Seocalcitol is 0.48±0.04 nM. However, in the intestine, the Kd for Seocalcitol is 1.43±0.19 nM)[2]. Seocalcitol (0.1-10 nM) induces cell differentiation in a dosedependent manner. A higher differentiating activity is observed for 1 nM Seocalcitol than for 1 nM VD3.
In vivo	Seocalcitol, a synthetic vitamin D analog, demonstrates lower hypercalcemic activity compared to 1,25(OH)2VD3. Its long-term intraperitoneal (IP) administration at 0.5 μg/kg body weight bi-daily significantly inhibits hepatocellular carcinoma (HCC) development in C3H/Sy mice[4]. Furthermore, when administered intraperitoneally to postnatal rats from days 4 to 12 at dosages of 0.38 or 1.25 μg/kg body weight per day, only the higher dosage (1.25 μg/kg) significantly attenuates weight gain, either as a standalone treatment or when combined with Dexamethasone, all-trans retinoic acid (RA), or retinoic acid[5].
Synonyms	EB 1089

Chemical Properties

Molecular Weight	454.68
Formula	C₃₀H₄₆O₃
Cas No.	134404-52-7
Smiles	[H][C@@]12CC[C@H]([C@H](C)\C=C\C=C\C(O)(CC)CC)[C@@]1(C)CCC\C2=C/C=C1/C[C@@H](O)C[C@H](O)C1=C
Relative Density.	1.06g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (109.97 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.1993 mL	10.9967 mL	21.9935 mL	109.9674 mL
5 mM	0.4399 mL	2.1993 mL	4.3987 mL	21.9935 mL
10 mM	0.2199 mL	1.0997 mL	2.1993 mL	10.9967 mL
20 mM	0.1100 mL	0.5498 mL	1.0997 mL	5.4984 mL
50 mM	0.0440 mL	0.2199 mL	0.4399 mL	2.1993 mL
100 mM	0.0220 mL	0.1100 mL	0.2199 mL	1.0997 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc