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Anti-Desmocollin 1 Polyclonal Antibody
Catalog No. TMAB-05097 Copy Product Info
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Anti-Desmocollin 1 Polyclonal Antibody is a Rabbit antibody targeting Desmocollin 1. Anti-Desmocollin 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Desmocollin 1 Polyclonal Antibody
Copy Product Info🥰Excellent
Catalog No. TMAB-05097
Anti-Desmocollin 1 Polyclonal Antibody is a Rabbit antibody targeting Desmocollin 1. Anti-Desmocollin 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF.
Anti-Desmocollin 1 Polyclonal Antibody
| Pack Size | Price | USA Stock | Global Stock | Quantity |
|---|---|---|---|---|
| 50 μL | $223 | 7-10 days | 7-10 days | |
| 100 μL | $372 | 7-10 days | 7-10 days | |
| 200 μL | $529 | 7-10 days | 7-10 days |
For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)
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For research use only—not for human use. No sales to individuals. Use as intended only.
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Bioactivity
Antigen Details
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| Description | Anti-Desmocollin 1 Polyclonal Antibody is a Rabbit antibody targeting Desmocollin 1. Anti-Desmocollin 1 Polyclonal Antibody can be used in IHC-P,IHC-Fr,IF. |
| Ig Type | IgG |
| Reactivity | Human (predicted:Mouse,Rat,Dog,Pig,Cow,Horse) |
| Verified Activity | Tissue/cell: human lung carcinoma; 4% Paraformaldehyde-fixed and paraffin-embedded; Antigen retrieval: citrate buffer (0.01 M, pH 6.0), Boiling bathing for 15 min; Block endogenous peroxidase by 3% Hydrogen peroxide for 30 min; Blocking buffer (normal goat serum) at 37℃ for 20 min; Incubation: Anti-CDHF1 Polyclonal Antibody, Unconjugated (TMAB-05097) 1: 200, overnight at 4°C, followed by conjugation to the secondary antibody and DAB staining |
| Application | |
| Recommended Dose | IHC-P: 1:100-500; IHC-Fr: 1:100-500; IF: 1:100-500 |
| Antibody Type | Polyclonal |
| Host Species | Rabbit |
| Subcellular Localization | Cell membrane; Single-pass type I membrane protein. Cell junction, desmosome. |
| Tissue Specificity | Strongly expressed in epidermis, less in lymph node and tongue. |
| Construction | Polyclonal Antibody |
| Purification | Protein A purified |
| Appearance | Liquid |
| Formulation | 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol. |
| Concentration | 1mg/ml |
| Research Background | The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Alternative splicing results in two transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008] |
| Immunogen | KLH conjugated synthetic peptide: human Desmocollin 1 |
| Antigen Species | Human |
| Gene Name | DSC1 |
| Gene ID | |
| Protein Name | Desmocollin-1 |
| Uniprot ID | |
| Function | Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms. Linked to the keratinization of epithelial tissues. |
| Molecular Weight | Theoretical: 85 kDa. |
| Stability & Storage | Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. |
| Transport | Shipping with blue ice. |
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