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Sialidase-1 Protein, Human, Recombinant (His)

Catalog No. TMPJ-01287
Synonyms: NEU1, NANH, Lysosomal Sialidase, G9 Sialidase, Sialidase-1, N-Acetyl-α-Neuraminidase 1, N-Acetyl-Alpha-Neuraminidase 1, Acetylneuraminyl Hydrolase

Sialidase-1 belongs to the N-acetyl-a neuraminidase family. Sialidase-1 is expressed in many tissues; it is highly expressed in the pancreas, and weakly expressed in the brain. Sialidase-1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Deficiencies in the human enzyme Sialidase-1 leads to sialidosis, a rare lysosomal storage disease. Sialidase-1 has been shown to interact with Cathepsin A (protective protein), β-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.

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Sialidase-1 Protein, Human, Recombinant (His)
Pack Size Availability Price/USD Quantity
10 μg 5 days $ 184.00
50 μg 5 days $ 545.00
500 μg 5 days $ 1,900.00
1 mg 5 days $ 2,730.00
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Biological Description
Technical Params
Product Properties
Description Sialidase-1 belongs to the N-acetyl-a neuraminidase family. Sialidase-1 is expressed in many tissues; it is highly expressed in the pancreas, and weakly expressed in the brain. Sialidase-1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Deficiencies in the human enzyme Sialidase-1 leads to sialidosis, a rare lysosomal storage disease. Sialidase-1 has been shown to interact with Cathepsin A (protective protein), β-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.
Species Human
Expression System Human Cells
Tag C-6His
Accession Number Q99519
Synonyms NEU1, NANH, Lysosomal Sialidase, G9 Sialidase, Sialidase-1, N-Acetyl-α-Neuraminidase 1, N-Acetyl-Alpha-Neuraminidase 1, Acetylneuraminyl Hydrolase
Amino Acid Glu48-Leu415
Construction Recombinant Human N-acetyl-alpha-Neuraminidase 1 is produced by our Mammalian expression system and the target gene encoding Glu48-Leu415 is expressed with a 6His tag at the C-terminus.
Protein Purity Greater than 95% as determined by reducing SDS-PAGE. (QC verified)
Molecular Weight 39-50 KDa, reducing conditions
Endotoxin Less than 0.1 ng/µg (1 EU/µg) as determined by LAL test.
Formulation Supplied as a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 50% Glycerol, pH 7.4.
Stability & Storage

Store at ≤-70°C, stable for 6 months after receipt. Store at ≤-70°C, stable for 3 months under sterile conditions after opening. Please minimize freeze-thaw cycles.

Shipping

The product is shipped on dry ice/polar packs. Upon receipt, store it immediately at the temperature listed below.

Research Background Sialidase-1 belongs to the N-acetyl-a neuraminidase family. Sialidase-1 is expressed in many tissues; it is highly expressed in the pancreas, and weakly expressed in the brain. Sialidase-1 is a lysosomal enzyme, which cleaves terminal sialic acid residues from substrates such as glycoproteins and glycolipids. Deficiencies in the human enzyme Sialidase-1 leads to sialidosis, a rare lysosomal storage disease. Sialidase-1 has been shown to interact with Cathepsin A (protective protein), β-galactosidase and N-acetylgalactosamine-6-sulfate sulfatase in a multienzyme complex.

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Keywords

Sialidase-1 Protein, Human, Recombinant (His) NEU1 NANH Lysosomal Sialidase G9 Sialidase Sialidase-1 N-Acetyl-α-Neuraminidase 1 NEU-1 N-Acetyl-Alpha-Neuraminidase 1 NEU 1 N-Acetyl-a-Neuraminidase 1 Acetylneuraminyl Hydrolase recombinant recombinant-proteins proteins protein

 

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