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Anti-CD55/DAF Antibody-APC (4E459)
🥰Excellent
Catalog No. TMAY-03306A
Anti-CD55/DAF Antibody-APC (4E459) is a APC-conjugated Rabbit antibody targeting CD55/DAF. Anti-CD55/DAF Antibody-APC (4E459) can be used in FCM.
Anti-CD55/DAF Antibody-APC (4E459)
Anti-CD55/DAF Antibody-APC (4E459)
🥰Excellent
Catalog No. TMAY-03306A
Anti-CD55/DAF Antibody-APC (4E459) is a APC-conjugated Rabbit antibody targeting CD55/DAF. Anti-CD55/DAF Antibody-APC (4E459) can be used in FCM.
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Product Introduction
Bioactivity
Related Conjugates and Formulations
Antigen Details
Chemical Properties
| Description | Anti-CD55/DAF Antibody-APC (4E459) is a APC-conjugated Rabbit antibody targeting CD55/DAF. Anti-CD55/DAF Antibody-APC (4E459) can be used in FCM. |
| Ig Type | Monoclonal Rabbit IgG |
| Clone | 4E459 |
| Reactivity | Mouse |
| Verified Activity | Flow cytometric analysis of Mouse CD55 expression on mouse splenocytes. BABL/c splenocytes were stained with APC-conjugated anti-Mouse CD55. The histogram were derived from gated events with the forward and side light-scatter characteristics of intact cells. |
| Application | FCM |
| Recommended Dose | 5 μl/Test, 0.1 mg/ml |
| Antibody Type | Monoclonal |
| Host Species | Rabbit |
| Construction | This antibody was obtained from a rabbit immunized with purified, recombinant Mouse CD55 / DAF (rM CD55 / DAF; TMPY-02616; Q61475; Met1-Thr361) and conjugated with APC under optimum conditions, the unreacted APC was removed. |
| Purification | Protein A |
| Appearance | Liquid |
| Formulation | PBS solution containing 0.5% BSA and 0.09% sodium azide |
| Research Background | CD55, also well known as decay-accelerating factor (DAF), is a member of the RCA (regulators of complement activation) family characterized by four to 30 SCRs (short consensus repeats) in their plasma-exposed regions. It is a major regulator of the alternative and classical pathways of complement activation and is expressed on all serum-exposed cells. CD55 is physiologically acting as an inhibitor of the complement system, but is also broadly expressed in malignant tumours. DAF seems to exert different functions beyond its immunological role such as promotion of tumorigenesis, decrease of complement mediated tumor cell lysis, autocrine loops for cell rescue and evasion of apoptosis, neoangiogenesis, invasiveness, cell motility. It is commonly hijacked by invading pathogens, including many enteroviruses and uropathogenic Escherichia coli, to promote cellular attachment prior to infection. This 70-75 kDa glycoprotein CD55 containing four SCR modules is involved in the regulation of the complement cascade. It inhibits complement activation by suppressing the function of C3/C5 convertases, thereby limiting local generation or deposition of C3a/C5a and membrane attack complex (MAC or C5b-9) production. DAF has been identified as a ligand for an activation-associated, seven-transmembrane lymphocyte receptor, CD97, which is a receptor mediating attachment and infection of several viruses and bacteria. In addition, it has been shown that DAF regulates the interplay between complement and T cell immunity in vivo, and thus may be implicated in immune and tumor biology. |
| Conjucates | APC |
| Others Formats | Unconjugated/PerCP/FITC/PE |
| Antibody Types Available | 5 |
| Immunogen | Recombinant Mouse CD55 / DAF protein (TMPY-02616) |
| Antigen Species | Mouse |
Stability & Storage
| Stability & Storage | Store at 2°C-8°C for 12 months, do not freeze. Keep away from direct sunlight. Sodium azide is toxic to cells and should be disposed of properly. Flush with large volumes of water during disposal. |
| Transport | Shipping with blue ice. |
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