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Cauloside A

😃Good
Catalog No. TN1476Cas No. 17184-21-3
Alias Leontoside A

Cauloside A is a bioactive triterpenoid saponin derived from Cimicifuga thalictroides with multifunctional anti-inflammatory, antimicrobial, cytotoxic, hemolytic, and molluscicidal activities. Cauloside A induces concentration-dependent and time-dependent mitochondriotoxic actions, rapidly increasing the cellular respiration rate followed by a dramatic decline within minutes. Mechanistic studies show Cauloside A disrupts mitochondrial membrane integrity, impairing mitochondrial function and contributing to potent biological effects relevant to therapeutic development.

Cauloside A

Cauloside A

😃Good
Purity: 99.87%
Catalog No. TN1476Alias Leontoside ACas No. 17184-21-3
Cauloside A is a bioactive triterpenoid saponin derived from Cimicifuga thalictroides with multifunctional anti-inflammatory, antimicrobial, cytotoxic, hemolytic, and molluscicidal activities. Cauloside A induces concentration-dependent and time-dependent mitochondriotoxic actions, rapidly increasing the cellular respiration rate followed by a dramatic decline within minutes. Mechanistic studies show Cauloside A disrupts mitochondrial membrane integrity, impairing mitochondrial function and contributing to potent biological effects relevant to therapeutic development.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$76-In Stock
5 mg$183-In Stock
10 mg$269-In Stock
25 mg$459-In Stock
50 mg$668-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.87%
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Product Introduction

Bioactivity
Description
Cauloside A is a bioactive triterpenoid saponin derived from Cimicifuga thalictroides with multifunctional anti-inflammatory, antimicrobial, cytotoxic, hemolytic, and molluscicidal activities. Cauloside A induces concentration-dependent and time-dependent mitochondriotoxic actions, rapidly increasing the cellular respiration rate followed by a dramatic decline within minutes. Mechanistic studies show Cauloside A disrupts mitochondrial membrane integrity, impairing mitochondrial function and contributing to potent biological effects relevant to therapeutic development.
SynonymsLeontoside A
Chemical Properties
Molecular Weight604.81
FormulaC35H56O8
Cas No.17184-21-3
SmilesC[C@]12[C@@]([C@]3(C)[C@@](CC1)([C@@](CO)(C)[C@@H](O[C@H]4[C@H](O)[C@@H](O)[C@@H](O)CO4)CC3)[H])(CC=C5[C@@]2(C)CC[C@]6(C(O)=O)[C@]5(CC(C)(C)CC6)[H])[H]
Relative Density.no data available
ColorWhite
AppearanceSolid
Storage & Solubility Information
Storagekeep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
DMSO: 80 mg/mL (132.27 mM), Sonication is recommeded.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM1.6534 mL8.2671 mL16.5341 mL82.6706 mL
5 mM0.3307 mL1.6534 mL3.3068 mL16.5341 mL
10 mM0.1653 mL0.8267 mL1.6534 mL8.2671 mL
20 mM0.0827 mL0.4134 mL0.8267 mL4.1335 mL
50 mM0.0331 mL0.1653 mL0.3307 mL1.6534 mL
100 mM0.0165 mL0.0827 mL0.1653 mL0.8267 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
1 Enter information below:
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2 Enter the in vivo formulation:
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Keywords

Cauloside A
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