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Demcizumab

Catalog No. T76788 CAS 1243262-17-0

Synonyms: OMP 21M18

Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent Notch pathway inhibitor. Demcizumab is effective in multiple cancer models, both alone and in combination with chemotherapy agents.

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Demcizumab

Demcizumab, CAS 1243262-17-0

Pack Size	Availability	Price/USD
1 mg	In stock	$ 372.00
5 mg	In stock	$ 933.00
10 mg	In stock	$ 1,490.00

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Description	Demcizumab (OMP 21M18) is an anti-DLL4 monoclonal antibody. Demcizumab is a potent Notch pathway inhibitor. Demcizumab is effective in multiple cancer models, both alone and in combination with chemotherapy agents.
In vitro	Demcizumab (0-100 μg/mL) binds to human DLL4 but not to mouse DLL4 and blocks the interaction of DLL4 with the Notch1 receptor in FACS binding assays[3]. Following treatment with Demcizumab at 20 μg/mL for 48 hours, there is a reduction in the mRNA expression of HES1 and DTX1 in PDTALL cells[4]. Demcizumab (0-80 μg/mL, 1, 2, or 3 days) promotes cell death and early apoptosis in PDTALL13 cells[4].
In vivo	Demcizumab (10 mg/kg, i.p., once weekly) in combination with Irinotecan (7.5 mg/kg) demonstrates a significant antitumor effect in KRASWT and KRASMT colorectal cancer xenograft models[2]. Demcizumab, either alone or in combination with Irinotecan (7.5 mg/kg), is effective against OMP-C8 colon tumors[3]. Administration of Demcizumab (20 mg/kg/week, intraperitoneal injection) increases the survival rate of NRG mice injected with irradiated PDTALL13 cells[4].

Synonyms	OMP 21M18
Molecular Weight	145.65 (kDa)
CAS No.	1243262-17-0

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References and Literature

1. Smith DC, et al. A phase I dose escalation and expansion study of the anticancer stem cell agent demcizumab (anti-DLL4) in patients with previously treated solid tumors. Clin Cancer Res. 2014 Dec 15;20(24):6295-303. 2. Fischer M, et al. Anti-DLL4 inhibits growth and reduces tumor-initiating cell frequency in colorectal tumors with oncogenic KRAS mutations. Cancer Res 2011;71:1520-5. 3. Hoey T, et al. DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency. Cell Stem Cell 2009;5:168–77. 4. Xiong H, et al. Spleen plays a major role in DLL4-driven acute T-cell lymphoblastic leukemia. Theranostics. 2021 Jan 1;11(4):1594-1608.

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Keywords

Demcizumab 1243262-17-0 Neuroscience Proteases/Proteasome Stem Cells Gamma-secretase OMP 21M18 inhibitor inhibit

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