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Anti-Siglec-2/CD22 Antibody (1M79) (Synonyms: SIGLEC-2, SIGLEC2, CD22 molecule)

Name: Anti-Siglec-2/CD22 Antibody (1M79)
Brand: TargetMol
SKU: TMAY-02165
Rating: 4.5 (1 reviews)

Catalog No. TMAY-02165 Copy Product Info

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Anti-Siglec-2/CD22 Antibody (1M79) is a Mouse antibody targeting Siglec-2/CD22. Anti-Siglec-2/CD22 Antibody (1M79) can be used in FCM.

Anti-Siglec-2/CD22 Antibody (1M79)

Copy Product Info

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Catalog No. TMAY-02165

Synonyms SIGLEC-2, SIGLEC2, CD22 molecule

Anti-Siglec-2/CD22 Antibody (1M79) is a Mouse antibody targeting Siglec-2/CD22. Anti-Siglec-2/CD22 Antibody (1M79) can be used in FCM.

Anti-Siglec-2/CD22 Antibody
(1M79)

Pack Size	Price	USA Stock	Global Stock	Quantity
100 μL	$198	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Product Introduction

Bioactivity

Description	Anti-Siglec-2/CD22 Antibody (1M79) is a Mouse antibody targeting Siglec-2/CD22. Anti-Siglec-2/CD22 Antibody (1M79) can be used in FCM.
Synonyms	SIGLEC-2, SIGLEC2, CD22 molecule
Ig Type	Mouse IgG1
Clone	1M79
Reactivity	Human
Specificity	Human Siglec-2/CD22
Verified Activity	Flow cytometric analysis of Human CD22 expression on human whole blood lymphocytes. Cells were stained with purified anti-Human CD22, then a FITC-conjugated second step antibody. The fluorescence histograms were derived from gated events with the forward and side light-scatter characteristics of viable lymphocytes.
Application	FCM
Recommended Dose	FCM: 1:25-1:100
Antibody Type	Monoclonal
Host Species	Mouse
Construction	This antibody was produced from a hybridoma resulting from the fusion of a mouse myeloma with B cells obtained from a mouse immunized with purified, recombinant Human CD22 / Siglec-2 (rh CD22 / Siglec-2; TMPY-02034; P20273-1; Met1-Arg687). The IgG fraction of the cell culture supernatant was purified by Protein A affinity chromatography.
Purification	Protein A
Appearance	Liquid
Formulation	0.2 μm filtered solution in PBS with 10% Trehalose, pH7.0
Research Background	CD22 is a member of the immunoglobulin superfamily, SIGLEC family of lectins. It is first expressed in the cytoplasm of pro-B and pre-B cells, and on the surface as B cells mature to become IgD+. CD22 serves as an adhesion receptor for sialic acid-bearing ligands expressed on erythrocytes and all leukocyte classes. In addition to its potential role as a mediator of intercellular interactions, signal transduction through CD22 can activate B cells and modulate antigen receptor signaling in vitro. The phenotype of CD22-deficient mice suggests that CD22 is primarily involved in the generation of mature B cells within the bone marrow, blood, and marginal zones of lymphoid tissues. CD22 recruits the tyrosine phosphatase Src homology 2 domain-containing phosphatase 1 (SHP-1) to immunoreceptor tyrosine-based inhibitory motifs (ITIMs) and inhibits B-cell receptor (BCR)-induced Ca2+ signaling on normal B cells. CD22 interacts specifically with ligands carrying alpha2-6-linked sialic acids. As an inhibitory coreceptor of the B-cell receptor (BCR), CD22 plays a critical role in establishing signalling thresholds for B-cell activation. Like other coreceptors, the ability of CD22 to modulate B-cell signalling is critically dependent upon its proximity to the BCR, and this in turn is governed by the binding of its extracellular domain to alpha2,6-linked sialic acid ligands. However, genetic studies in mice reveal that some CD22 functions are regulated by ligand binding, whereas other functions are ligand-independent and may only require expression of an intact CD22 cytoplasmic domain at the B-cell surface. CD19 regulates CD22 phosphorylation by augmenting Lyn kinase activity, while CD22 inhibits CD19 phosphorylation via SHP-1.Cancer ImmunotherapyImmune CheckpointImmunotherapyTargeted Therapy

Related Conjugates and Formulations

Conjucates	Unconjugated
Others Formats	PerCP/FITC/PE
Antibody Types Available	4

Antigen Details

Immunogen	Recombinant Protein: Human CD22 / Siglec-2 Protein (TMPY-02034)
Antigen Species	Human
Biology Area	Cancer Drug Targets, ITIM/ITAM Immunoreceptors and Related Molecules

Chemical Properties

Stability & Storage

Stability & Storage	Store at 2°C-8°C for 1 month. Store at -20°C or -80°C for 12 months. Avoid repeated freeze-thaw cycles. Preservative-Free.
Transport	Shipping with blue ice.

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Keywords

SIGLEC 2

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