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SR59230A hydrochloride

Name: SR59230A hydrochloride
Brand: TargetMol
SKU: T13016L
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13016LCas No. 1135278-41-9

Alias SR59230A HCl

SR59230A hydrochloride (SR59230A HCl) is a blood-brain permeable, selective and highly potent β3-adrenergic receptor antagonist that inhibits ultradian brown adipose tissue thermogenesis and interrupts associated paroxysmal brain and body heating.

SR59230A hydrochloride

🥰Excellent

Purity: 99.49%

Catalog No. T13016LAlias SR59230A HClCas No. 1135278-41-9

Pack Size	Price	Availability
1 mg	$38	In Stock
5 mg	$82	In Stock
10 mg	$118	In Stock
25 mg	$193	In Stock
50 mg	$286	In Stock
100 mg	$423	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock

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Batch Information

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Purity:99.49%

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	SR59230A hydrochloride (SR59230A HCl) is a blood-brain permeable, selective and highly potent β3-adrenergic receptor antagonist that inhibits ultradian brown adipose tissue thermogenesis and interrupts associated paroxysmal brain and body heating.
Targets&IC50	β1-adrenoceptor:408 nM , β3-adrenoceptor:40 nM , β2-adrenoceptor:648 nM
In vitro	SR59230A hydrochloride (100 nM-50 μM; 24 hours) can reduce cell viability in a dose-dependent manner in Neuro-2A, BE(2)C and SK-N-BE(2) NB cell lines. [1]
In vivo	MDMA (20 mg/kg) caused a slow rise in body temperature, reaching a maximum temperature increase of 1.8°C at 130 min post-injection. SR59230A hydrochloride (0.5 mg/kg) was able to slightly but significantly alleviate the slow rise in body temperature induced by MDMA. SR59230A hydrochloride (5 mg/kg) exhibited a significant and pronounced early hypothermic response to MDMA. [2]
Synonyms	SR59230A HCl

Chemical Properties

Molecular Weight	361.91
Formula	C₂₁H₂₈ClNO₂
Cas No.	1135278-41-9
Smiles	N(C[C@@H](COC1=C(CC)C=CC=C1)O)[C@@H]2C=3C(CCC2)=CC=CC3.Cl
Relative Density.	no data available
Color	White
Appearance	Solid

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL(552.62 mM), Sonication is recommended.

H2O: 1 mg/mL(2.76 mM), Sonication is recommended.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7631 mL	13.8156 mL	27.6312 mL	138.1559 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.5526 mL	2.7631 mL	5.5262 mL	27.6312 mL
10 mM	0.2763 mL	1.3816 mL	2.7631 mL	13.8156 mL
20 mM	0.1382 mL	0.6908 mL	1.3816 mL	6.9078 mL
50 mM	0.0553 mL	0.2763 mL	0.5526 mL	2.7631 mL
100 mM	0.0276 mL	0.1382 mL	0.2763 mL	1.3816 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc