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SR59230A hydrochloride

Name: SR59230A hydrochloride
Brand: TargetMol
SKU: T13016L
Price: 38 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T13016LCas No. 1135278-41-9

Alias SR59230A HCl

SR59230A hydrochloride (SR59230A HCl) is a blood-brain permeable, selective and highly potent β3-adrenergic receptor antagonist that inhibits ultradian brown adipose tissue thermogenesis and interrupts associated paroxysmal brain and body heating.

SR59230A hydrochloride

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Purity: 99.49%

Catalog No. T13016LAlias SR59230A HClCas No. 1135278-41-9

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$38	In Stock	In Stock
5 mg	$82	In Stock	In Stock
10 mg	$118	In Stock	In Stock
25 mg	$193	In Stock	In Stock
50 mg	$286	In Stock	In Stock
100 mg	$423	In Stock	In Stock
1 mL x 10 mM (in DMSO)	$98	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.49%

Appearance:Solid

Color:White

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COA HPLC HNMR

Product Introduction

Bioactivity

Description	SR59230A hydrochloride (SR59230A HCl) is a blood-brain permeable, selective and highly potent β3-adrenergic receptor antagonist that inhibits ultradian brown adipose tissue thermogenesis and interrupts associated paroxysmal brain and body heating.
Targets&IC50	β1-adrenoceptor:408 nM , β3-adrenoceptor:40 nM , β2-adrenoceptor:648 nM
In vitro	SR59230A hydrochloride (100 nM-50 μM; 24 hours) can reduce cell viability in a dose-dependent manner in Neuro-2A, BE(2)C and SK-N-BE(2) NB cell lines. [1]
In vivo	MDMA (20 mg/kg) caused a slow rise in body temperature, reaching a maximum temperature increase of 1.8°C at 130 min post-injection. SR59230A hydrochloride (0.5 mg/kg) was able to slightly but significantly alleviate the slow rise in body temperature induced by MDMA. SR59230A hydrochloride (5 mg/kg) exhibited a significant and pronounced early hypothermic response to MDMA. [2]
Synonyms	SR59230A HCl

Chemical Properties

Molecular Weight	361.91
Formula	C₂₁H₂₈ClNO₂
Cas No.	1135278-41-9
Smiles	N(C[C@@H](COC1=C(CC)C=CC=C1)O)[C@@H]2C=3C(CCC2)=CC=CC3.Cl
Relative Density.	no data available

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 200 mg/mL (552.62 mM), Sonication is recommended.

H2O: 1 mg/mL (2.76 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 5 mg/mL (13.82 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

H2O/DMSO

	1mg	5mg	10mg	50mg
1 mM	2.7631 mL	13.8156 mL	27.6312 mL	138.1559 mL

DMSO

	1mg	5mg	10mg	50mg
5 mM	0.5526 mL	2.7631 mL	5.5262 mL	27.6312 mL
10 mM	0.2763 mL	1.3816 mL	2.7631 mL	13.8156 mL
20 mM	0.1382 mL	0.6908 mL	1.3816 mL	6.9078 mL
50 mM	0.0553 mL	0.2763 mL	0.5526 mL	2.7631 mL
100 mM	0.0276 mL	0.1382 mL	0.2763 mL	1.3816 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc