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PKA Inhibitor Fragment (6-22) amide TFA

🥰Excellent
Catalog No. T75888
Alias PKI-(6-22)-amide TFA, PKA Inhibitor Fragment (6-22) amide TFA(121932-06-7 Free base)

PKA Inhibitor Fragment (6-22) amide TFA (PKA Inhibitor Fragment (6-22) amide TFA) is a highly potent inhibitor of cAMP-dependent protein kinase A (PKA) with a Ki of 2.8 nM and reverses the pain-relieving effects of low levels of morphine in mice.

PKA Inhibitor Fragment (6-22) amide TFA
Other Forms of PKA Inhibitor Fragment (6-22) amide TFA:
PKA inhibitor fragment (6-22) amide AcetateT21674L
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PKA Inhibitor Fragment (6-22) amide TFA

🥰Excellent
Purity: 99.87%
Catalog No. T75888Alias PKI-(6-22)-amide TFA, PKA Inhibitor Fragment (6-22) amide TFA(121932-06-7 Free base)
PKA Inhibitor Fragment (6-22) amide TFA (PKA Inhibitor Fragment (6-22) amide TFA) is a highly potent inhibitor of cAMP-dependent protein kinase A (PKA) with a Ki of 2.8 nM and reverses the pain-relieving effects of low levels of morphine in mice.
Pack SizePriceUSA WarehouseGlobal WarehouseQuantity
1 mg$149-In Stock
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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]
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Purity:99.87%
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Product Introduction

Bioactivity
Description
PKA Inhibitor Fragment (6-22) amide TFA (PKA Inhibitor Fragment (6-22) amide TFA) is a highly potent inhibitor of cAMP-dependent protein kinase A (PKA) with a Ki of 2.8 nM and reverses the pain-relieving effects of low levels of morphine in mice.
Targets&IC50
PKA:2.8 nM (Ki)
SynonymsPKI-(6-22)-amide TFA, PKA Inhibitor Fragment (6-22) amide TFA(121932-06-7 Free base)
Chemical Properties
Molecular Weight1982.08
FormulaC82H131F3N28O26
SmilesCC[C@H](C)[C@@H](C(N)=O)NC([C@H](C)NC([C@H](CC(N)=O)NC([C@H](CCCNC(N)=N)NC([C@H](CCCNC(N)=N)NC(CNC([C@H]([C@H](O)C)NC([C@H](CCCNC(N)=N)NC(CNC([C@H](CO)NC([C@H](C)NC([C@H]([C@@H](C)CC)NC([C@@H](NC([C@H](CC(O)=O)NC([C@H](C)NC([C@@H](NC([C@@H](N)[C@H](O)C)=O)CC1=CC=C(C=C1)O)=O)=O)=O)CC2=CC=CC=C2)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O
ColorWhite
AppearanceSolid
SequenceThr-Tyr-Ala-Asp-Phe-Ile-Ala-Ser-Gly-Arg-Thr-Gly-Arg-Arg-Asn-Ala-Ile
Sequence ShortTYADFIASGRTGRRNAI-NH2
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture,store under nitrogen,store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
Solubility Information
H2O: 40 mg/mL (20.18 mM), Sonication is recommended.
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.5045 mL2.5226 mL5.0452 mL25.2260 mL
5 mM0.1009 mL0.5045 mL1.0090 mL5.0452 mL
10 mM0.0505 mL0.2523 mL0.5045 mL2.5226 mL
20 mM0.0252 mL0.1261 mL0.2523 mL1.2613 mL

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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2OTargetMol | reagent mix well and clarify
For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.
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Keywords

PKA
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