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Dalvastatin

Name: Dalvastatin
Brand: TargetMol
SKU: T25285
Price: 191 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T25285Cas No. 132100-55-1

Alias RG-12561, RG12561, RG 12561

Dalvastatin (RG-12561) is an orally available inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis.Dalvastatin competitively inhibits rat hepatic HMG-CoA reductase with an IC50 value of 3.4 nmol / l. Dalvastatin inhibits cholesterol biosynthesis in liver sections in rat experiments with an ED50 value of 0.9.

Dalvastatin

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Purity: 98.07%

Catalog No. T25285Alias RG-12561, RG12561, RG 12561Cas No. 132100-55-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$191	In Stock	In Stock
5 mg	$480	In Stock	In Stock
10 mg	$687	In Stock	In Stock
25 mg	$1,080	-	In Stock
50 mg	$1,480	-	In Stock
100 mg	$1,990	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products.If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:98.07%

Appearance:Oil

Color:Yellow

Resource Download

COA HNMR HPLC

Product Introduction

Bioactivity

Description	Dalvastatin (RG-12561) is an orally available inhibitor of HMG-CoA reductase and cholesterol-lowering synthesis.Dalvastatin competitively inhibits rat hepatic HMG-CoA reductase with an IC50 value of 3.4 nmol / l. Dalvastatin inhibits cholesterol biosynthesis in liver sections in rat experiments with an ED50 value of 0.9.
Synonyms	RG-12561, RG12561, RG 12561

Chemical Properties

Molecular Weight	386.5
Formula	C₂₄H₃₁FO₃
Cas No.	132100-55-1
Smiles	C(=C/[C@H]1C[C@H](O)CC(=O)O1)\C2=C(CC(C)(C)CC2(C)C)C3=CC(C)=C(F)C=C3
Relative Density.	1.134g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (129.37 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5873 mL	12.9366 mL	25.8732 mL	129.3661 mL
5 mM	0.5175 mL	2.5873 mL	5.1746 mL	25.8732 mL
10 mM	0.2587 mL	1.2937 mL	2.5873 mL	12.9366 mL
20 mM	0.1294 mL	0.6468 mL	1.2937 mL	6.4683 mL
50 mM	0.0517 mL	0.2587 mL	0.5175 mL	2.5873 mL
100 mM	0.0259 mL	0.1294 mL	0.2587 mL	1.2937 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc