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Sabizabulin

Name: Sabizabulin
Brand: TargetMol
SKU: T17228
Price: 73 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T17228Cas No. 1332881-26-1

Alias VERU-111, ABI-231

Sabizabulin (ABI-231) is a potent, orally bioavailable α- and β-tubulin inhibitor that is active against melanoma and prostate cancer cell lines. Sabizabulin inhibits tumor growth and metastatic phenotypes of cervical cancer cells by targeting HPV E6 and E7 and is also being studied in prostate cancer.

Sabizabulin

🥰Excellent

Purity: 99.79%

Catalog No. T17228Alias VERU-111, ABI-231Cas No. 1332881-26-1

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$73	In Stock	In Stock
2 mg	$106	In Stock	In Stock
5 mg	$176	In Stock	In Stock
10 mg	$283	In Stock	In Stock
25 mg	$542	In Stock	In Stock
50 mg	$893	-	In Stock
100 mg	$1,470	-	In Stock
200 mg	$1,980	-	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. However, due to objective factors, there is a small probability that the synthesis may not be successful during the R&D process. We appreciate your understanding. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:99.79%

Resource Download

COA HNMR LCMS

Product Introduction

Bioactivity

Description	Sabizabulin (ABI-231) is a potent, orally bioavailable α- and β-tubulin inhibitor that is active against melanoma and prostate cancer cell lines. Sabizabulin inhibits tumor growth and metastatic phenotypes of cervical cancer cells by targeting HPV E6 and E7 and is also being studied in prostate cancer.
In vitro	METHODS: BT474 and SKBR3 cells were treated with Sabizabulin (ABI-231) (4, 8, 12, 16 nM), and cell growth inhibition was measured by MTS assay. RESULTS Sabizabulin (ABI-231) significantly inhibited the growth of BT474 and SKBR3 cells in a concentration-dependent manner with IC50 values of 9.07 and 8.18 nM, respectively, and had low cytotoxicity. [1]
In vivo	METHODS: Sabizabulin (ABI-231) (17 mg/kg/20 mg/kg, oral, three weeks) was used to treat BT474 xenograft/HCI-12 PDX model mice and its therapeutic effect was observed. RESULTS Sabizabulin (ABI-231) significantly reduced the tumor volume and tumor wet weight of terminal BT474 xenograft mice, inhibited tumor growth and suppressed lung metastasis in HCI-12 PDX model mice. [1]
Synonyms	VERU-111, ABI-231

Chemical Properties

Molecular Weight	377.39
Formula	C₂₁H₁₉N₃O₄
Cas No.	1332881-26-1
Smiles	COc1cc(cc(OC)c1OC)C(=O)c1c[nH]c(n1)-c1c[nH]c2ccccc12
Relative Density.	1.306 g/cm3 (Predicted)
Color	Yellow
Appearance	Solid

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (132.49 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.3 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.6498 mL	13.2489 mL	26.4978 mL	132.4889 mL
5 mM	0.5300 mL	2.6498 mL	5.2996 mL	26.4978 mL
10 mM	0.2650 mL	1.3249 mL	2.6498 mL	13.2489 mL
20 mM	0.1325 mL	0.6624 mL	1.3249 mL	6.6244 mL
50 mM	0.0530 mL	0.2650 mL	0.5300 mL	2.6498 mL
100 mM	0.0265 mL	0.1325 mL	0.2650 mL	1.3249 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc