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Vatinoxan hydrochloride

Name: Vatinoxan hydrochloride
Brand: TargetMol
SKU: T13285
Rating: 4.5 (1 reviews)

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Catalog No. T13285Cas No. 130466-38-5

Alias MK-467 hydrochloride, L-659066 hydrochloride

Vatinoxan hydrochloride is an antagonist of the peripheral α2 adrenergic receptors.

Vatinoxan hydrochloride

😃Good

Catalog No. T13285Alias MK-467 hydrochloride, L-659066 hydrochlorideCas No. 130466-38-5

Vatinoxan hydrochloride is an antagonist of the peripheral α2 adrenergic receptors.

Pack Size	Price	Availability
25 mg	$5,970	8-10 weeks
50 mg	$9,540	8-10 weeks
100 mg	$13,400	8-10 weeks

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Product Introduction

Bioactivity

Description	Vatinoxan hydrochloride is an antagonist of the peripheral α2 adrenergic receptors.
In vivo	When given simultaneously i.v Vatinoxan alone increases cardiac index and tissue oxygen delivery and has no deleterious adverse effects.In a dose-dependent manner Vatinoxan attenuates or prevents dexmedetomidine's systemic hemodynamic effects. A 50:1 dose ratio (Vatinoxan:dexmedetomidine) induces the least alterations in cardiovascular function[1]. Vatinoxan dose-dependently reduces bradycardia associated with dexmedetomidine and shortens the sedative effect without changing its quality. Vatinoxan may help reduce heart rate reduction in cats consciously administering dexmedetomidine[2].
Synonyms	MK-467 hydrochloride, L-659066 hydrochloride

Chemical Properties

Molecular Weight	454.97
Formula	C₂₀H₂₇ClN₄O₄S
Cas No.	130466-38-5
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 133 mg/mL (292.33 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.1979 mL	10.9897 mL	21.9795 mL	109.8974 mL
5 mM	0.4396 mL	2.1979 mL	4.3959 mL	21.9795 mL
10 mM	0.2198 mL	1.0990 mL	2.1979 mL	10.9897 mL
20 mM	0.1099 mL	0.5495 mL	1.0990 mL	5.4949 mL
50 mM	0.0440 mL	0.2198 mL	0.4396 mL	2.1979 mL
100 mM	0.0220 mL	0.1099 mL	0.2198 mL	1.0990 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments

A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH₂O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.

Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH₂O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

All types of co-solvents required for the protocol, such asDMSO, PEG300/ PEG400, Tween 80, SBE-β-CD, corn oil are available for purchase on the TargetMol website with a simple click.

Dose Conversion

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc