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Vatinoxan hydrochloride

Name: Vatinoxan hydrochloride
Brand: TargetMol
SKU: T13285
Rating: 4.5 (1 reviews)

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Catalog No. T13285Cas No. 130466-38-5

Alias MK-467 hydrochloride, L-659066 hydrochloride

Vatinoxan hydrochloride is an antagonist of the peripheral α2 adrenergic receptors.

Vatinoxan hydrochloride

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Catalog No. T13285Alias MK-467 hydrochloride, L-659066 hydrochlorideCas No. 130466-38-5

Vatinoxan hydrochloride is an antagonist of the peripheral α2 adrenergic receptors.

Pack Size	Price	USA Warehouse	Global Warehouse
25 mg	$5,970	8-10 weeks	8-10 weeks
50 mg	$9,540	8-10 weeks	8-10 weeks
100 mg	$13,400	8-10 weeks	8-10 weeks

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Product Introduction

Bioactivity

Description	Vatinoxan hydrochloride is an antagonist of the peripheral α2 adrenergic receptors.
In vivo	When given simultaneously i.v Vatinoxan alone increases cardiac index and tissue oxygen delivery and has no deleterious adverse effects.In a dose-dependent manner Vatinoxan attenuates or prevents dexmedetomidine's systemic hemodynamic effects. A 50:1 dose ratio (Vatinoxan:dexmedetomidine) induces the least alterations in cardiovascular function[1]. Vatinoxan dose-dependently reduces bradycardia associated with dexmedetomidine and shortens the sedative effect without changing its quality. Vatinoxan may help reduce heart rate reduction in cats consciously administering dexmedetomidine[2].
Synonyms	MK-467 hydrochloride, L-659066 hydrochloride

Chemical Properties

Molecular Weight	454.97
Formula	C₂₀H₂₇ClN₄O₄S
Cas No.	130466-38-5
Smiles	Cl.[H][C@@]12C[C@@]3(CNC(=O)N3CCNS(C)(=O)=O)CCN1CCc1c2oc2ccccc12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

H2O: 133 mg/mL (292.33 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.1979 mL	10.9897 mL	21.9795 mL	109.8974 mL
5 mM	0.4396 mL	2.1979 mL	4.3959 mL	21.9795 mL
10 mM	0.2198 mL	1.0990 mL	2.1979 mL	10.9897 mL
20 mM	0.1099 mL	0.5495 mL	1.0990 mL	5.4949 mL
50 mM	0.0440 mL	0.2198 mL	0.4396 mL	2.1979 mL
100 mM	0.0220 mL	0.1099 mL	0.2198 mL	1.0990 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc