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Morniflumate

Name: Morniflumate
Brand: TargetMol
SKU: T19636
Price: 39 USD
Availability: InStock
Rating: 5 (10 reviews)

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Catalog No. T19636Cas No. 65847-85-0

Alias UP-164, UP164, UP 164, Niflam, Morniflu

Morniflumate (Niflam) is a nonsteroidal anti-inflammatory drug. It is used to treat inflammation.

Morniflumate

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Purity: 99.12%

Catalog No. T19636Alias UP-164, UP164, UP 164, Niflam, MornifluCas No. 65847-85-0

Morniflumate (Niflam) is a nonsteroidal anti-inflammatory drug. It is used to treat inflammation.

Pack Size	Price	USA Warehouse	Global Warehouse
1 mg	$39	In Stock	In Stock
5 mg	$98	In Stock	In Stock
10 mg	$172	In Stock	In Stock
25 mg	$289	In Stock	In Stock
50 mg	$413	In Stock	In Stock
100 mg	$589	In Stock	In Stock
200 mg	$797	-	In Stock
1 mL x 10 mM (in DMSO)	$107	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.

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Batch Information

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Purity:99.12%

Appearance:Viscous

Color:White

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COA HNMR MS LCMS

Product Introduction

Morniflumate AI Summary

Morniflumate displays notable bioactivity across different assays and models. It is effective in blocking the entry of the Ebola Virus, with AC50 values ranging from 631.0 nM to 7.943 µM. In terms of SARS-CoV-2, it exhibits varying degrees of antiviral activity: it inhibits SARS-CoV-2 induced cytotoxicity in Caco-2 cells with an inhibition rate of 68.23% at 10 µM after 48 hours, but shows low effectiveness in HRCE cells with a hit score of 0.09756. Additionally, it offers 10.12% inhibition of SARS-CoV-2 3CL-Pro protease at 20 µM. The compound also reduces cytotoxicity in VERO-6 cells at 10 µM, but with weak potency (IC50 > 20000 nM). Beyond antiviral activities, Morniflumate significantly inhibits human HDAC6 (62.01%) and interacts with multiple human and rat receptors, displaying both agonist and antagonist activities in various assays. It has binding affinities for receptors like KCNH2, SLC6A3, and OPRK1, and shows activity towards enzymes such as PDE4D and PTGS2, indicating a diverse range of biological interactions..

Note: Summary generated by AI. Data source: ChEMBL

Bioactivity

Description	Morniflumate (Niflam) is a nonsteroidal anti-inflammatory drug. It is used to treat inflammation.
Synonyms	UP-164, UP164, UP 164, Niflam, Morniflu

Chemical Properties

Molecular Weight	395.38
Formula	C₁₉H₂₀F₃N₃O₃
Cas No.	65847-85-0
Smiles	FC(F)(F)c1cccc(Nc2ncccc2C(=O)OCCN2CCOCC2)c1
Relative Density.	1.312 g/cm3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 60 mg/mL (151.75 mM), Sonication is recommended.

In Vivo Formulation

10% DMSO+40% PEG300+5% Tween 80+45% Saline: 2 mg/mL (5.06 mM), Sonication is recommended.

Please add the solvents sequentially, clarifying the solution as much as possible before adding the next one. Dissolve by heating and/or sonication if necessary. Working solution is recommended to be prepared and used immediately. The formulation provided above is for reference purposes only. In vivo formulations may vary and should be modified based on specific experimental conditions.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5292 mL	12.6461 mL	25.2921 mL	126.4606 mL
5 mM	0.5058 mL	2.5292 mL	5.0584 mL	25.2921 mL
10 mM	0.2529 mL	1.2646 mL	2.5292 mL	12.6461 mL
20 mM	0.1265 mL	0.6323 mL	1.2646 mL	6.3230 mL
50 mM	0.0506 mL	0.2529 mL	0.5058 mL	2.5292 mL
100 mM	0.0253 mL	0.1265 mL	0.2529 mL	1.2646 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc