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Desmethyl ferroquine

Name: Desmethyl ferroquine
Brand: TargetMol
SKU: T11006
Rating: 4.5 (1 reviews)

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Catalog No. T11006Cas No. 903546-18-9

Alias SSR97213

Desmethyl ferroquine is the active and major metabolite of Ferroquine.Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains. Ferroquine is an antimalarial.

Desmethyl ferroquine

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Catalog No. T11006Alias SSR97213Cas No. 903546-18-9

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Product Introduction

Bioactivity

Description	Desmethyl ferroquine is the active and major metabolite of Ferroquine.Desmethyl ferroquine shows significant activity against Chloroquine-susceptible and resistant P. falciparum strains. Ferroquine is an antimalarial.
In vitro	Ferroquine's apparent terminal half-life is estimated to be 15.9 days. However, the main metabolite of the same activity, desmethyl ironquine (DMFQ), has a longer t1/2z, and the total average estimated time is 31.4 days.
Synonyms	SSR97213

Chemical Properties

Molecular Weight	419.73
Formula	C₂₂H₂₂ClFeN₃
Cas No.	903546-18-9
Smiles	C(NC=1C2=C(N=CC1)C=C(Cl)C=C2)[C-]34[Fe+2]56789%10%11(C3(CNC)=[CH]5[CH]6=[CH]74)[CH-]%12[CH]8=[CH]9[CH]%10=[CH]%11%12
Relative Density.	no data available

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 2.5 mg/mL (5.96 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.3825 mL	11.9124 mL	23.8248 mL	119.1242 mL
5 mM	0.4765 mL	2.3825 mL	4.7650 mL	23.8248 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc