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DSO-5a
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Catalog No. T79231Cas No. 2195411-63-1
DSO-5a, a potent and selective orally active BB3 agonist, is a DMAKO-00 derivative that enhances ppar-γ activity via BB3 and stimulates ERK1/2 phosphorylation. It is utilized in diabetes-related research [1].
DSO-5a
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Catalog No. T79231Cas No. 2195411-63-1
DSO-5a, a potent and selective orally active BB3 agonist, is a DMAKO-00 derivative that enhances ppar-γ activity via BB3 and stimulates ERK1/2 phosphorylation. It is utilized in diabetes-related research [1].
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 25 mg | $1,520 | 6-8 weeks | |
| 50 mg | $1,980 | 6-8 weeks | |
| 100 mg | $2,500 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | DSO-5a, a potent and selective orally active BB3 agonist, is a DMAKO-00 derivative that enhances ppar-γ activity via BB3 and stimulates ERK1/2 phosphorylation. It is utilized in diabetes-related research [1]. |
| In vitro | DSO-5a (50 nM; 60min) induced IP-1 accumulation in hBB3-HEK cells with a pEC50 of 8.485 and elicited a potent calcium response with a pEC50 of 7.964 [1]. At 500 nM, it induced IP-1 accumulation in mBB3-HEK cells with a pEC50 of 7.262 and a calcium response with a pEC50 of 7.174 [1]. DSO-5a also activated ERK1/2 in both hBB3-H1299 and mBB3-HEK cells in a dose-dependent manner (0-100 nM) within 8 minutes [1]. |
| In vivo | DSO-5a (3-30 mg/kg; P.O.; 30 minutes) dose-dependently reduced glycemic variability in C57BL/6 mice [1], and at 10 mg/kg/day for 2-4 weeks, it lowered blood glucose levels in diabetic db/db mice [1]. |
| Molecular Weight | 440.45 |
| Formula | C23H24N2O7 |
| Cas No. | 2195411-63-1 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature. |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% Saline/PBS/ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLSaline/PBS/ddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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