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ROCK-IN-1

Name: ROCK-IN-1
Brand: TargetMol
SKU: T13419
Price: 117 USD
Availability: InStock
Rating: 5 (10 reviews)

🥰Excellent

Catalog No. T13419Cas No. 934387-35-6

ROCK-IN-1, a potent ROCK inhibitor, effectively inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM. ROCK-IN-1 is applicable in the study of neurological disorders and inflammation-related diseases.

ROCK-IN-1

🥰Excellent

Catalog No. T13419Cas No. 934387-35-6

Pack Size	Price	USA Warehouse	Global Warehouse	Quantity
1 mg	$117	In Stock	In Stock
5 mg	$289	In Stock	In Stock

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In Stock Estimated shipping dateUSA Warehouse[1-2 days] Global Warehouse[5-7 days]

This molecule is a custom-made product. TargetMol has an excellent synthesis team with the experience and capability to provide you with cost-effective products. If you have any questions, please feel free to contact us. We are committed to serving you wholeheartedly.

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Batch Information

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Purity:>99.99%

Appearance:Solid

Color:Yellow

Resource Download

COA HNMR LCMS FNMR

Product Introduction

Bioactivity

Description	ROCK-IN-1, a potent ROCK inhibitor, effectively inhibits ROCK2-mediated signaling with an IC50 value of 1.2 nM. ROCK-IN-1 is applicable in the study of neurological disorders and inflammation-related diseases.
Targets&IC50	ROCK2:1.2 nM
In vitro	With an EC50 of 200 nM, ROCK-IN-1 exhibits potent cellular efficacy[1].

Chemical Properties

Molecular Weight	335.37
Formula	C₂₀H₁₈FN₃O
Cas No.	934387-35-6
Smiles	CC(N)c1ccc(cc1-c1ccc(F)cc1)C(=O)Nc1ccncc1
Relative Density.	1.31g/cm3

Storage & Solubility Information

Storage

store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.

Solubility Information

DMSO: 50 mg/mL (149.09 mM), Sonication is recommended.

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.9818 mL	14.9089 mL	29.8178 mL	149.0891 mL
5 mM	0.5964 mL	2.9818 mL	5.9636 mL	29.8178 mL
10 mM	0.2982 mL	1.4909 mL	2.9818 mL	14.9089 mL
20 mM	0.1491 mL	0.7454 mL	1.4909 mL	7.4545 mL
50 mM	0.0596 mL	0.2982 mL	0.5964 mL	2.9818 mL
100 mM	0.0298 mL	0.1491 mL	0.2982 mL	1.4909 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the stock solution preparation method and in vivo formula preparation method:

For example, if the intended dosage is 10 mg/kg for animals weighing 20 g , with a dosing volume of 100 μL per animal, TargetMol | Animal experiments

and a total of 10 animals are to be administered, using a formulation of TargetMol | reagent

10% DMSO+ 40% PEG300+ 5% Tween 80+ 45% Saline/PBS/ddH₂O , the resulting working solution concentration would be 2 mg/mL.

Stock Solution Preparation:

Dissolve 2 mg of the compound in 100 μL DMSO TargetMol | reagent to obtain a stock solution at a concentration of 20 mg/mL . If the required concentration exceeds the compound's known solubility, please contact us for technical support before proceeding.

Preparation of the In Vivo Formulation:

1) Add 100 μL of the DMSO TargetMol | reagent stock solution to 400 μL PEG300 and mix thoroughly until the solution becomes clear.

2) Add 50 μL Tween 80 and mix well until fully clarified.

3) Add 450 μL Saline,PBS or ddH₂O TargetMol | reagent and mix thoroughly until a homogeneous solution is obtained.

This example is provided solely to demonstrate the use of the In Vivo Formulation Calculator and does not constitute a recommended formulation for any specific compound. Please select an appropriate dissolution and formulation strategy based on your experimental model and route of administration.

All co-solvents required for this protocol, includingDMSO, PEG300/PEG400, Tween 80, SBE-β-CD, and Corn oil, are available for purchase on the TargetMol website.

Dose Conversion

You can also refer to dose conversion for different animals. More Dose Conversion

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc