DKK1 Protein, Mouse, Recombinant

Name: DKK1 Protein, Mouse, Recombinant
Brand: TargetMol
SKU: TMPS-00021
Price: 119 USD
Availability: InStock
Rating: 5 (10 reviews)

(Synonyms: DKK-1, Dickkopf-1) Copy Product Info

Synonyms: DKK-1, Dickkopf-1

Catalog No. TMPS-00021 Copy Product Info

DKK1 Protein, Mouse, Recombinant is expressed in CHO Cells. The accession number is O54908.

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Pack Size	Price	USA Stock	Global Stock
5 µg	$119	-	In Stock
10 µg	$198	-	In Stock
20 µg	$323	7-10 days	7-10 days
50 µg	$622	7-10 days	7-10 days
100 µg	$987	7-10 days	7-10 days
200 µg	$1,660	7-10 days	7-10 days
500 µg	$3,190	7-10 days	7-10 days
1 mg	$5,280	7-10 days	7-10 days

For In stock only · Estimated delivery: USA Stock (1-2 days) Global Stock (5-7 days)

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For research use only—not for human use. No sales to individuals. Use as intended only.

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Purity:> 95% as analyzed by SDS-PAGE

Appearance:Lyophilized powder

Color:White

Resource Download

COA User Guide of Recombinant Proteins

Product Introduction

Bioactivity

Bioactivity	ED 50 < 6.0 µg/ml, measured in stimulation of alkaline phosphatase activity using CCl-226 cells.
Description	DKK1 Protein, Mouse, Recombinant is expressed in CHO Cells. The accession number is O54908.
Species	Mouse
Expression System	CHO Cells
Tag	Tag Free
Accession Number	O54908
Construction	Ser30-His272
Protein Purity	> 95% as determined by SDS-PAGE
Endotoxin	< 0.2 EU/μg of protein as determined by the LAL method.
Formulation	Lyophilized from a 0.2 μm filtered solution in PBS.
Reconstitution	Reconstitute the lyophilized protein in sterile deionized water. The product concentration should not be less than 100 μg/ml. Before opening, centrifuge the tube to collect powder at the bottom. After adding the reconstitution buffer, avoid vortexing or pipetting for mixing.
Synonyms	DKK-1, Dickkopf-1
Research Background	Dickkopf related protein 1 (DKK-1) is a chemokine that belongs to the DKK protein family, which also includes DKK-2, DKK-3 and DKK-4. DKK-1 was originally identified as a Xenopus head forming molecule that behaves as an antagonist for Wnt signaling. It is one of the most up-regulated genes during androgen-potentiated balding, with DKK-1 messenger RNA up-regulated a few hours after DHT treatment of hair follicles at the dermal papilla in vitro. Neutralizing bodies against DKK-1 reverses DHT effects on outer root sheath keratinocytes. DKK-1 expression is attenuated by L-threonate, a metabolite of ascorbate in vitro. DKK-1 promotes LRP6 internalization and degradation as it forms a ternary complex with the cell surface receptor Kremen. DKK-1 not only functions in head formation during development, but also regulates joint remodeling and bone formation indicating its potential role in the pathogenesis of rheumatoid arthritis and multiple myeloma.

Chemical Properties

Molecular Weight

19~20 kDa (Reducing conditions)

Storage & Solubility Information

Shipping	In general, lyophilized powders are shipped with blue ice, while solutions are shipped with dry ice.
Storage	Upon receiving, this product remains stable for up to 6 months at lower than -70°C. Upon reconstitution, the product should be stable for up to 1 week at 4°C or up to 3 months at -20°C. For long term storage it is recommended that a carrier protein (example 0.1% BSA) be added. Avoid repeated freeze-thaw cycles.